Influence of donor type, stem cell source and conditioning on outcomes after haploidentical transplant for lymphoma

Article Article scientifique Article Influence of donor type, stem cell source and conditioning on outcomes after haploidentical transplant for lymphoma - a LWP-EBMT study eng 2020 author Bazarbachi Ali author Boumendil Ariane author Finel Hervé author Castagna Luca author Dominietto Alida author Blaise Didier author Diez-Martin Jose L author Tischer Johanna author Gülbas Zafer author Wallet Hélène L author Corral Lucia L author Mohty Mohamad author Koc Yener author Yakoub-Agha Ibrahim author Schmid Christoph Johann 83745 author El Cheikh Jean author Arat Mutlu author Forcade Edouard author Dreger Peter author Rocha Vanderson author García Gonzalo G author Chalandon Yves 644957 author Ferra Christelle author Orvain Corentin author Robinson Stephen author Montoto Silvia author Sureda Anna 745-756 10.1111/bjh.16182 31498883 0007-1048 Haploidentical stem cell transplantation (haploSCT) is becoming a major transplant modality for lymphoma. To assess the effects of donor characteristics, stem cell source and conditioning on outcomes, we identified 474 adults with Hodgkin (HL; 240), peripheral T-cell (PTCL; 88), diffuse large B-cell (77), mantle cell (40) or follicular lymphoma (FL; 29), who received haploSCT with post-transplant cyclophosphamide. Median follow-up of alive patients was 32 months. On multivariate analysis, acute graft-versus-host disease (GVHD) grade 2-4 was lower with offspring donors or bone marrow cells, whereas extensive chronic GVHD was higher in partial response at haploSCT or when using sisters, haploidentical donors beyond first degree, or female donors in male patients. Progression-free survival (PFS) was better for FL, HL and PTCL, whereas overall survival (OS) was better for HL and PTCL. Complete remission at haploSCT improved PFS and OS whereas these were negatively affected by cytomegalovirus donor positive/recipient positive status. No other donor characteristics (age, gender, human leucocyte antigen mismatch, ABO incompatibility) affected PFS or OS except use of haploidentical donors beyond first degree, which negatively affected OS. PFS and OS are mostly influenced by disease status and lymphoma subtype, supporting the use of any first degree haploidentical family member as a donor. Conditioning Donor type Haploidentical transplant Lymphoma Stem cell source. Dewey 616 56 Département de médecine 221 false 1216 Leucémie et transplantation allogénique de cellules souches hématopoïétiques 982 British Journal of Haematology 188 5 3d7d02ad-e584-4169-abaf-b665ad38bf20 Article (Published version) Restricted bjh.16182.pdf 193898 application/pdf restrictedAccess Faculté de médecine / Section de médecine clinique / Département de médecine

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Influence of donor type, stem cell source and conditioning on outcomes after haploidentical transplant for lymphoma - a LWP-EBMT study	British Journal of Haematology			2020	330	0

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Schmid, Christoph Johann