Investigating the Function of Mitochondrial RNA Granules

Diplôme Thèse Investigating the Function of Mitochondrial RNA Granules eng 2019-12-18 author Zaganelli Sofia 837252 director Martinou Jean-Claude 27293 10.13097/archive-ouverte/unige:136734 urn:nbn:ch:unige-1367345 Sc. Vie 42 Mitochondrial gene expression is a fundamental process for mitochondrial respiration. Several steps of mitochondrial gene expression appear to be spatially organized in two distinct structures containing both proteins and nucleic acids. The mitochondrial genome is present in hundreds of copies in mammalian cells, packed into structures named nucleoids. Once the mtDNA gets transcribed into long polycistronic RNAs, the newly synthesized mitochondrial RNAs form distinct foci, together with specific proteins, named mitochondrial RNA granules (MRGs). Different functions have been ascribed to MRGs, however to date there is still lack of information about the relevance of MRGs in mitochondrial gene expression and, more generally, in mitochondrial biology. Here, we present 3 complementary projects that aim at addressing the importance of MRGs by investigating: (1) novel MRG components; (2) the biophysical properties of MRGs, applying super-resolution microscopy; (3) proteins involved in the biogenesis and regulation of MRGs, using a high-throughput RNAi screen. Mitochondria RNA granules Mitochondrial Gene Expression Dewey 570 PhD salary iGE3 46 Département de biologie cellulaire 165 false 837 Groupe Martinou 3cf3fb74-bfef-4e0a-8776-cd27b482d869 Thesis Restricted Thesis_Deposited_SZaganelli.pdf 73435520 application/pdf Private 2021-06-04 6c3576f8c19bf8f435f3de01a386b33b7358c9b6da550c44c69d018ef34a0673 restrictedAccess Faculté des sciences / Section de biologie / Département de biologie cellulaire

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Investigating the Function of Mitochondrial RNA Granules				2019	626	4

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Zaganelli, Sofia