A systematic review of phage therapy applied to bone and joint infections: an analysis of success rates, treatment modalities and safety

Article Article scientifique Revue de la littérature A systematic review of phage therapy applied to bone and joint infections: an analysis of success rates, treatment modalities and safety eng 2021 2021-12-10 author Geneviere Joseph 835601 author McCallin Shawna 913683 author Csaki Huttner Angela 788122 author Pham Truong-Thanh 0000-0003-0284-7080 529004 author Suva Domizio 590318 1148-1156 10.1302/2058-5241.6.210073 35003759 2058-5241 PMC8722473 Bone and joint infections are difficult to treat, and increasing antibiotic resistance has only made them more challenging. This has led to renewed interest in phage therapy (PT). The aim of this systematic review was to determine success rate, current treatment modalities and safety of PT in bone and joint infections.A systematic search of PubMed, EMBASE and Cochrane databases as well as the journal PHAGE for literature published between January 2000 and April 2021 was conducted according to PRISMA guidelines to identify all human studies assessing bacteriophages as therapy for bone and joint infections. All study designs and patient populations were eligible. The review's primary outcome was success rate.Twenty records describing a total of 51 patients and 52 treatment episodes were included. No randomized controlled studies were identified. The overall success rate was 71% (n = 37/52). Topical administration alone was the most frequent administration route (85%, n = 44/52). Antibiotics were administered concomitantly with PT in the majority of treatments (79%, n = 41/52), and surgery was performed for 87% (n = 45/52) of treatment episodes. Four minor adverse events related to PT were reported, representing 8% (n = 4/52) of treatment episodes.PT for bone and joint infections has not been evaluated in any randomized controlled clinical study, and current administration modalities are highly variable between case reports and case series. While publications included here show potential benefit and few adverse effects, clinical trials are warranted to assess the efficacy of PT for bone and joint infections and determine optimal treatment modalities. Bacteriophages Bone and joint infection Orthopaedics Osteomyelitis Periprosthetic joint infection Phage therapy Systematic review Dewey 616 Dewey 617 57 Département de chirurgie 222 56 Département de médecine 221 false 955 Mécanismes physiopathologiques de l'arthrose 960 https://doi.org/10.1302/2058-5241.6.210073 EFORT open reviews 6 12 e98d4ea3-9359-4cbe-8386-4f1f03cc6f13 Article (Published version) Public Article-scientifique-from-europePmc.pdf 791940 application/pdf CC BY-NC-4.0 c36949aa-6365-43e5-8668-bb408185b96b Supplemental data Public appendix_i.pdf 254014 application/pdf CC BY-NC-4.0 openAccess Faculté de médecine / Section de médecine clinique / Département de chirurgie Faculté de médecine / Section de médecine clinique / Département de médecine

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A systematic review of phage therapy applied to bone and joint infections: an analysis of success rates, treatment modalities and safety	EFORT open reviews			2021	262	431

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Geneviere, Joseph