Neurophysiological assessment of Alzheimer's disease individuals by a single electroencephalographic marker

Article Article professionnel Article Neurophysiological assessment of Alzheimer's disease individuals by a single electroencephalographic marker eng 2015 author Lizio Roberta author Del Percio Claudio author Marzano Nicola author Soricelli Andrea author Yener Görsev G author Başar Erol author Mundi Ciro author De Rosa Salvatore author Triggiani Antonio Ivano author Ferri Raffaele author Arnaldi Dario author Nobili Flavio Mariano author Cordone Susanna author Lopez Susanna author Carducci Filippo author Santi Giulia author Gesualdo Loreto author Rossini Paolo M author Cavedo Enrica author Mauri Margherita 835304 author Frisoni Giovanni 810190 author Babiloni Claudio 159-177 10.3233/JAD-143042 26444753 1387-2877 Here we presented a single electroencephalographic (EEG) marker for a neurophysiological assessment of Alzheimer's disease (AD) patients already diagnosed by current guidelines. The ability of the EEG marker to classify 127 AD individuals and 121 matched cognitively intact normal elderly (Nold) individuals was tested. Furthermore, its relationship to AD patients' cognitive status and structural brain integrity was examined. Low-resolution brain electromagnetic tomography (LORETA) freeware estimated cortical sources of resting state eyes-closed EEG rhythms. The EEG marker was defined as the ratio between the activity of parieto-occipital cortical sources of delta (2-4 Hz) and low-frequency alpha (8-10.5 Hz) rhythms. Results showed 77.2% of sensitivity in the recognition of the AD individuals; 65% of specificity in the recognition of the Nold individuals; and 0.75 of area under the receiver-operating characteristic curve. Compared to the AD subgroup with the EEG maker within one standard deviation of the Nold mean (EEG-), the AD subgroup with EEG+ showed lower global cognitive status, as revealed by Mini-Mental State Evaluation score, and more abnormal values of white-matter and cerebrospinal fluid normalized volumes, as revealed by structural magnetic resonance imaging. We posit that cognitive and functional status being equal, AD patients with EEG+ should receive special clinical attention due to a neurophysiological "frailty". EEG+ label can be also used in clinical trials (i) to form homogeneous groups of AD patients diagnosed by current guidelines and (ii) as end-point to evaluate intervention effects. Aged Alzheimer Disease/physiopathology Biomarkers Brain Mapping Case-Control Studies Cognition Disorders/physiopathology Electroencephalography Female Humans Italy Magnetic Resonance Imaging Male Middle Aged Occipital Lobe/physiopathology ROC Curve Rest Turkey Dewey 616.89 60 Département de psychiatrie 225 false 853 Troubles de mémoire et maladie d'Alzeimer 935 Journal of Alzheimer's disease 49 1 491cc644-dfce-4474-b778-e448d5ef5d07 Article (Accepted version) Restricted 491.pdf 1324795 application/pdf restrictedAccess Faculté de médecine / Section de médecine clinique / Département de psychiatrie

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Neurophysiological assessment of Alzheimer's disease individuals by a single electroencephalographic marker	Journal of Alzheimer's disease			2015	522	0

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