Physical activity programmes for patients undergoing neo-adjuvant chemoradiotherapy for rectal cancer: A systematic review and meta-analysis

Article Article scientifique Méta-analyse Physical activity programmes for patients undergoing neo-adjuvant chemoradiotherapy for rectal cancer: A systematic review and meta-analysis eng 2021-12-23 author Latrille Marianne SophieLéa 0000-0002-2965-5364 833487 author Buchs Nicolas 516487 author Ris Frédéric 53083 author Kossler Thibaud 0000-0001-9196-9076 500516 e27754 10.1097/MD.0000000000027754 34941028 0025-7974 PMC8702187 Background: Patients diagnosed with localized rectal cancer should undergo Neoadjuvant Radio-Chemotherapy (NACRT) followed, a few weeks later, by surgical resection. NACRT is known to cause significant decline in the physical and psychological health of patients. This literature review aims to summarize the effects of a prehabilitation programme during and/or after NACRT but before surgery. Methods: Articles included in this review have been selected by two independent researchers on Pubmed, Google Scholar, and Cochrane databases with the following terms: “Rectal Cancer AND Physical Activity” and “Exercise AND Rectal Cancer.” Results: We obtained 560 articles. We selected 12 of these, representing 7 series but only one randomized study, constituting 153 patients in total. Most studies included have considerable variation in their prehabilitation programmes, in terms of supervision, training content, frequency, intensity, duration, and temporality, in regard to NACRT and surgery. Implementing a prehabilitation programme during NACRT seems feasible and safe, with adherence ranging from 58% to 100%. VO2max (maximal oxygen consumption during incremental exercise) was improved in three of the studies during the prehabilitation programme. No significant difference in the step count, 6-minute-walk test, or quality of life was seen. Conclusions: Prehabilitation programmes during NACRT for localized rectal cancer patients are safe and feasible; however, due to considerable variation in the prehabilitation programmes and their small size, impact on fitness, quality of life, and surgical outcome are unknown. Larger randomized studies are needed. Exercise Neo-adjuvant radiochemotherapy treatment Physical activity Prehabilitation Rectal cancer Dewey 616 Dewey 617 57 Département de chirurgie 222 56 Département de médecine 221 false 562 Transplantation et hépatologie 905 Medicine 100 51 5895a6f4-0592-4624-897b-c448fbf4b00e Article (Published version) Public medi-100-e27754.pdf 492327 application/pdf CC BY-NC-4.0 openAccess Faculté de médecine / Section de médecine clinique / Département de chirurgie Faculté de médecine / Section de médecine clinique / Département de médecine

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Physical activity programmes for patients undergoing neo-adjuvant chemoradiotherapy for rectal cancer: A systematic review and meta-analysis	Medicine			2021	158	194

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Latrille, Marianne SophieLéa