Large-scale brain network dynamics in very preterm children and relationship with socio-emotional outcomes : an exploratory study

Article Article scientifique Article Large-scale brain network dynamics in very preterm children and relationship with socio-emotional outcomes : an exploratory study eng 2022-11-03 2023-06 author Siffredi Vanessa 0000-0002-9137-0730 Division of Development and Growth, Department of Paediatrics, Gynaecology and Obstetrics, Geneva University Hospitals, Geneva, Switzerland. vanessa.siffredi@unige.ch.,Institute of Bioengineering, Center for Neuroprosthetics, Ecole Polytechnique Fédérale de Lausanne, Écublens, Switzerland. vanessa.siffredi@unige.ch.,Department of Radiology and Medical Informatics, Faculty of Medicine, University of Geneva, Geneva, Switzerland. vanessa.siffredi@unige.ch. 593615 author Liverani Maria Chiara Division of Development and Growth, Department of Paediatrics, Gynaecology and Obstetrics, Geneva University Hospitals, Geneva, Switzerland.,SensoriMotor, Affective and Social Development Laboratory, Faculty of Psychology and Educational Sciences, University of Geneva, Geneva, Switzerland. 698554 Section de psychologie (PSICO) author Freitas Lorena Division of Development and Growth, Department of Paediatrics, Gynaecology and Obstetrics, Geneva University Hospitals, Geneva, Switzerland.,Institute of Bioengineering, Center for Neuroprosthetics, Ecole Polytechnique Fédérale de Lausanne, Écublens, Switzerland.,Department of Radiology and Medical Informatics, Faculty of Medicine, University of Geneva, Geneva, Switzerland. 855354 author Tadros Daniel Division of Development and Growth, Department of Paediatrics, Gynaecology and Obstetrics, Geneva University Hospitals, Geneva, Switzerland.,Institute of Bioengineering, Center for Neuroprosthetics, Ecole Polytechnique Fédérale de Lausanne, Écublens, Switzerland.,Department of Radiology and Medical Informatics, Faculty of Medicine, University of Geneva, Geneva, Switzerland. 832207 author Farouj Younes Institute of Bioengineering, Center for Neuroprosthetics, Ecole Polytechnique Fédérale de Lausanne, Écublens, Switzerland.,Department of Radiology and Medical Informatics, Faculty of Medicine, University of Geneva, Geneva, Switzerland. 715620 author Borradori Tolsa Cristina Division of Development and Growth, Department of Paediatrics, Gynaecology and Obstetrics, Geneva University Hospitals, Geneva, Switzerland. 71921 Département de Pédiatrie, Gynécologie et Obstétrique (PETRI) author Van De Ville Dimitri 0000-0002-2879-3861 Division of Development and Growth, Department of Paediatrics, Gynaecology and Obstetrics, Geneva University Hospitals, Geneva, Switzerland.,Institute of Bioengineering, Center for Neuroprosthetics, Ecole Polytechnique Fédérale de Lausanne, Écublens, Switzerland.,Department of Radiology and Medical Informatics, Faculty of Medicine, University of Geneva, Geneva, Switzerland. 638484 Département de radiologie et informatique médicale (RADIO) author Hüppi Petra Susan Division of Development and Growth, Department of Paediatrics, Gynaecology and Obstetrics, Geneva University Hospitals, Geneva, Switzerland. 133591 Département de Pédiatrie, Gynécologie et Obstétrique (PETRI) author Ha-Vinh Leuchter Russia 0000-0001-9068-9670 Division of Development and Growth, Department of Paediatrics, Gynaecology and Obstetrics, Geneva University Hospitals, Geneva, Switzerland. 710706 Département de Pédiatrie, Gynécologie et Obstétrique (PETRI) Elisa Russia Tuyet Mai Ha Vinh Leuchter 2072-2080 10.1038/s41390-022-02342-y 36329223 0031-3998 PMC10313511 Background: Children born very preterm (VPT; <32 weeks' gestation) are at high risk of neurodevelopmental and behavioural difficulties associated with atypical brain maturation, including socio-emotional difficulties. The analysis of large-scale brain network dynamics during rest allows us to investigate brain functional connectivity and its association with behavioural outcomes. Methods: Dynamic functional connectivity was extracted by using the innovation-driven co-activation patterns framework in VPT and full-term children aged 6-9 to explore changes in spatial organisation, laterality and temporal dynamics of spontaneous large-scale brain activity (VPT, n = 28; full-term, n = 12). Multivariate analysis was used to explore potential biomarkers for socio-emotional difficulties in VPT children. Results: The spatial organisation of the 13 retrieved functional networks was comparable across groups. Dynamic features and lateralisation of network brain activity were also comparable for all brain networks. Multivariate analysis unveiled group differences in associations between dynamical functional connectivity parameters with socio-emotional abilities. Conclusion: In this exploratory study, the group differences observed might reflect reduced degrees of maturation of functional architecture in the VPT group in regard to socio-emotional abilities. Dynamic features of functional connectivity could represent relevant neuroimaging markers and inform on potential mechanisms through which preterm birth leads to neurodevelopmental and behavioural disorders. Impact: Spatial organisation of the retrieved resting-state networks was comparable between school-aged very preterm and full-term children. Dynamic features and lateralisation of network brain activity were also comparable across groups. Multivariate pattern analysis revealed different patterns of association between dynamical functional connectivity parameters and socio-emotional abilities in the very preterm and full-term groups. Findings suggest a reduced degree of maturation of the functional architecture in the very preterm group in association with socio-emotional abilities. Female Humans Infant, Newborn Child Infant, Extremely Premature Premature Birth Brain / diagnostic imaging Brain / physiology Emotions Gestational Age Magnetic Resonance Imaging Dewey 616.0757 Dewey 150 Dewey 618 Swiss National Science Foundation Building the path to resilience in preterm infants: a neuroimaging investigation of the impact of multisensory and neurocognitive interventions 163084 CH Projects 58 Département de pédiatrie, gynécologie et obstétrique 223 62 Département de radiologie et informatique médicale 227 108 Section de psychologie 71 false 150 L'imagerie cérébrale 184 552 Traitement d'images médicales 893 Pediatric research 93 7 48fb3340-ec2b-4f15-9587-1c1434dbd7b0 Article (Published version) Public Article-scientifique-from-unpaywall.pdf 1842477 application/pdf CC BY-4.0 c4470abf9b0abfe71ddc6e146d566d71719e07e92f8c1ceb750637ba41d2bf47 fefbd06c-f0c5-44d2-a30d-1f5fb6d14147 Supplemental data Public 41390_2022_2342_MOESM1_ESM.pdf 1888870 application/pdf a787a942ff130894e7f4440d46087601635bc14da706a5d2e229d7d8643d47fc openAccess Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale Faculté de psychologie et des sciences de l'éducation / Section de psychologie

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Large-scale brain network dynamics in very preterm children and relationship with socio-emotional outcomes : an exploratory study	Pediatric research			2023	99	180

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Tadros, Daniel