Sclerosing mucoepidermoid carcinoma with eosinophilia of the thyroid with molecular profiling and unusual immunoprofile : a case report

Article Article scientifique Rapport de cas Sclerosing mucoepidermoid carcinoma with eosinophilia of the thyroid with molecular profiling and unusual immunoprofile : a case report eng 2025-12 author Turberg Diane 829018 author Leboulleux Sophie 984598 Département de médecine (DEMED) author Zouggari Nawel 832877 author Du Bois Valentine Kenza 859121 author Mavromati Maria 810886 author Demarchi Marco Stefano 916698 Département de chirurgie (CHIRU) author Triponez Frédéric 28673 Département de chirurgie (CHIRU) author Sadow Peter author De Vito Claudio 795706 100031 10.1016/j.esmorc.2025.100031 3050-4619 https://www.sciencedirect.com/science/article/pii/S3050461925000309 Sclerosing mucoepidermoid carcinoma with eosinophilia (SMECE) is a rare thyroid tumor of unknown histogenesis with a high female predilection. It shows dual squamous and mucinous differentiation demonstrated by diffuse p63 or p40 expression and appreciable mucocytes, respectively. Thyroid transcription factor 1 (TTF1) is expressed in up to 50% of tumors while paired-box 8 (PAX8) and thyroglobulin are usually negative. No specific molecular signature has been described as a tumor driver. In this article, we present a 47-year-old man with an SMECE with peculiar histological and immunohistochemical features, including rare mucocytes highlighted by Alcian blue periodic acid—Schiff stain and diffuse cytokeratin 5/6 (CK5/6) expression while p40 was almost absent. TTF1 and PAX8 were weakly to moderately expressed. Molecular analysis, including next-generation sequencing and a solid fusion tumor assay, identified no driver alterations. A methylome analysis was inconclusive for a putative cell of origin. SMECE Thyroid tumor Molecular Tumor driver Thyroid carcinoma Squamous differentiation Molecular analysis Immunohistochemistry Cytohistological correlation Dewey 610 Dewey 616.07 Dewey 616 Dewey 617 137 Département de pathologie et immunologie 21F 56 Département de médecine 221 57 Département de chirurgie 222 4f7589ed-e44d-4850-a4d8-b0c1eccdfe48 Centre de recherche translationnelle en onco-hématologie 209 false 1263 MASLD/MASH et résistance à l'insuline 997 1388 Cancers de la femme 1040 902 Cancer du poumon et mésothéliome pleural malin 944 ESMO rare cancers 4 efe441ee-e990-4ed2-8c55-7f6ca910b294 Article (Published version) Public ESMO_2025_Mavromati.pdf 7647678 application/pdf CC BY-4.0 ebc734c1a3f70db7de79d9ce98f204f8bebd85ab491c66f285245a04e85bf5fd openAccess Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine clinique / Département de chirurgie Faculté de médecine / Centre de recherche translationnelle en onco-hématologie

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Sclerosing mucoepidermoid carcinoma with eosinophilia of the thyroid with molecular profiling and unusual immunoprofile : a case report	ESMO rare cancers			2025	16	14

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Turberg, Diane