The impact of living donor hypertension on later function of kidney graft in kidney transplantation

Article Article scientifique Article The impact of living donor hypertension on later function of kidney graft in kidney transplantation eng 2025-12-03 2025 author Huegli Sophie Division of Nephrology and Hypertension, Department of Medicine, Valais Romand Hospital (CHVR), Sion, Switzerland. 669398 author Jaques David Division of Nephrology and Hypertension, Department of Medicine, Geneva University Hospitals, Geneva, Switzerland. 633322 Département de médecine (DEMED) author Grouzmann Noémie Division of Nephrology and Hypertension, Department of Medicine, Geneva University Hospitals, Geneva, Switzerland. 974281 author Pasquier Théodore Division of Internal Medicine, Department of Medicine, Geneva University Hospitals, Geneva, Switzerland. 824727 author Hirt-Minkowski Patricia Living Kidney Donor Registry (SOL-DHR), University Hospital Basel, Basel, Switzerland. author Moll Solange Division of Pathology, Geneva University Hospitals, Geneva, Switzerland. 28349 Département de pathologie et immunologie (PATIM) author De Seigneux Matthey Sophie Division of Nephrology and Hypertension, Department of Medicine, Geneva University Hospitals, Geneva, Switzerland. 105798 Département de médecine (DEMED) author Ponte Belen Division of Nephrology and Hypertension, Department of Medicine, Geneva University Hospitals, Geneva, Switzerland. 89158 Département de médecine (DEMED) author Haidar Fadi Division of Nephrology and Hypertension, Department of Medicine, Geneva University Hospitals, Geneva, Switzerland. 960279 1686473 10.3389/fmed.2025.1686473 41416083 2296-858X PMC12710234 Introduction: The impact of hypertension (HT) of living donors on later kidney graft function remains insufficiently understood. Methods: We retrospectively reviewed recipients of living donor (LD) kidney transplant (KTX) at a single tertiary center from January 2003 to December 2021 with a follow-up until December 2022. LD blood pressure (BP) values obtained with office measurement and 24 h ambulatory BP monitoring (ABPM) were the main predictors, while recipient estimated glomerular filtration rate (eGFR) and proportion of kidney fibrosis on biopsies were the outcomes. Multivariate analyses were adjusted for pre-transplant donor characteristics: age, sex, ethnicity, body mass index (BMI) and eGFR. Results: 212 LD KTX recipients were included, with mean age 51 years. 133 were women (62.7%). 73 (34.4%) LD were hypertensive based on office BP. In a sub-group of 112 LD with ABPM, 64 (57.1%) were hypertensive. Office systolic blood pressure (SBP) was negatively associated with eGFR at 6 months, 1 year, 5 years and 10 years (p < 0.05). Office SBP was positively associated with kidney fibrosis at 1 year (p < 0.05). Those associations were not significant after multivariate adjustment. Discussion: In conclusion, while an adverse impact of LD HT on later kidney function and fibrosis was measured, this effect seemed negligible after accounting for other more relevant clinical characteristics. EGFR Fibrosis Hypertension Kidney transplant Living donor Dewey 616.07 Dewey 616 137 Département de pathologie et immunologie 21F 56 Département de médecine 221 false 897 Insuffisance rénale chronique 941 393 Analyse protéomique et Analyse génomique des maladies rénales 659 Frontiers in medicine 12 da65fed9-685c-405e-8c0d-758b3e72bec8 Article (Published version) Public Article_scientifique_from_unpaywall.pdf 765888 application/pdf CC BY-4.0 6713c52afc43b1afceda667c93ea5b00c1dc709dde94900f9ea6d42b55d03026 465189fa-5942-4cc2-a9a6-8f4384834bb4 Supplemental data Public data_sheet_1-4.pdf 68350 application/pdf 3f2877d941e7cfff5144f89cc073d2d228a1bf553cde0fbb98a94e0da8c6994c 4db0d80b-f029-421f-a033-db7cb39d69fd Supplemental data Public data_sheet_2.pdf 66961 application/pdf 916e8257b931815ae29ced9788b086bdde58ad5f493e6689d27c3023cfef6062 d034e95d-6d3a-4bc6-b67c-cfb141bb3073 Supplemental data Public data_sheet_3.pdf 26380 application/pdf e6a4c92a9cd6b5369f879a33f0e3bc41e9cfcb8e1c5dfbc1fd99f3c9a24df9fe openAccess Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie Faculté de médecine / Section de médecine clinique / Département de médecine

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The impact of living donor hypertension on later function of kidney graft in kidney transplantation	Frontiers in medicine			2025	5	40

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Pasquier, Théodore

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