Congenital toxoplasmosis after adalimumab treatment before pregnancy

Article Article scientifique Rapport de cas Congenital toxoplasmosis after adalimumab treatment before pregnancy eng 2021-08-11 2021-11 author Krull Eloise 823646 author Taraschi Gianmarco author Boffi El Amari Emmanuelle Jane 54906 author Pellegrinelli Jean-Marie author Martinez De Tejada Weber Begona 590919 4055-4059 10.1111/jog.14973 34382299 1447-0756 PMC9292430 https://obgyn.onlinelibrary.wiley.com/doi/10.1111/jog.14973 We present a case of congenital toxoplasmosis (TXP) in a woman with Toxoplasma gondii infection more than 6 months before conception. The woman has been treated with adalimumab for ankylosing spondylitis for 4 years until 5 months before conception. TXP serology at the first trimester was compatible with infection prior pregnancy. An ultrasound performed at 26 weeks gestation (WG) showed cerebral echogenic lesions compatible with intrauterine infection. Amniocentesis was performed which confirmed TXP fetal infection. Termination of the pregnancy was performed upon parent's requests and the fetal autopsy confirmed the diagnosis. Here, we discuss the potential role of immunosuppressive treatments, such as adalimumab, in the risk of congenital toxoplasmosis and the importance of counseling before pregnancy. Congenital toxoplasmosis Immunosuppressive therapy Infectious diseases Pregnancy Prenatal diagnosis Adalimumab / adverse effects Amniocentesis Female Humans Pregnancy Pregnancy Complications, Infectious Toxoplasmosis / diagnosis Toxoplasmosis / drug therapy Toxoplasmosis, Congenital / diagnosis Toxoplasmosis, Congenital / drug therapy Dewey 618 58 Département de pédiatrie, gynécologie et obstétrique 223 false 213 Martinez De Tejada Begona 272 Journal of obstetrics and gynaecology research 47 11 8e688156-df14-45a5-986e-377a8968a9ce Article (Published version) Public Article-scientifique-from-europePmc.pdf 569240 application/pdf CC BY-NC-ND-4.0 openAccess Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique

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Congenital toxoplasmosis after adalimumab treatment before pregnancy	Journal of obstetrics and gynaecology research			2021	254	207

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Krull, Eloise