A review of the biological and clinical implications of RAS-MAPK pathway alterations in neuroblastoma

Article Article scientifique Revue de la littérature A review of the biological and clinical implications of RAS-MAPK pathway alterations in neuroblastoma eng 2021-06-08 2021-06-08 author Mlakar Vid 842534 author Morel Edouard 822790 author Mlakar Simona 856065 author Ansari Djaberi Marc Georges 61572 author Gumy Pause Fabienne 0000-0002-2835-4367 133418 189 10.1186/s13046-021-01967-x 34103089 1756-9966 PMC8188681 Neuroblastoma is the most common extra-cranial solid tumor in children, representing approximately 8% of all malignant childhood tumors and 15% of pediatric cancer-related deaths. Recent sequencing and transcriptomics studies have demonstrated the RAS-MAPK pathway's contribution to the development and progression of neuroblastoma. This review compiles up-to-date evidence of this pathway's involvement in neuroblastoma. We discuss the RAS-MAPK pathway's general functioning, the clinical implications of its deregulation in neuroblastoma, and current promising therapeutics targeting proteins involved in signaling. ALK ERK1/2 Inhibitors MEK1/2 Neuroblastoma RAS RAS-MAPK RASopathie Dewey 618 58 Département de pédiatrie, gynécologie et obstétrique 223 false 564 Oncologie et hématologie pédiatriques 907 Journal of experimental & clinical cancer research 40 1 dc543584-e352-45d7-acd9-c2002930c73e Article (Published version) Public Article-scientifique-from-europePmc.pdf 1255013 application/pdf CC BY 1bc5fc55-6797-42bb-8674-84d1da04fa10 Appendix Public 13046_2021_1967_MOESM1_ESM.docx 115201 application/vnd.openxmlformats-officedocument.wordprocessingml.document openAccess Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique

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A review of the biological and clinical implications of RAS-MAPK pathway alterations in neuroblastoma	Journal of experimental & clinical cancer research			2021	252	383

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Morel, Edouard