Characteristics and Distribution of Intracranial Aneurysms in Patients with Autosomal Dominant Polycystic Kidney Disease Compared with the General Population: A Meta-Analysis

Article Article scientifique Méta-analyse Characteristics and Distribution of Intracranial Aneurysms in Patients with Autosomal Dominant Polycystic Kidney Disease Compared with the General Population: A Meta-Analysis eng 2023-02-20 2023-04-20 author Haemmerli Julien 0000-0001-5998-8541 Division of Neurosurgery, Department of Clinical Neurosciences, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland. 659636 author Morel Sandrine 0000-0003-1538-3553 Division of Neurosurgery, Department of Clinical Neurosciences, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland.,Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland. 654076 Département de pathologie et immunologie (PATIM) author Georges Marc Division of Neurosurgery, Department of Clinical Neurosciences, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland. 822392 author Haidar Fadi 0000-0002-8133-1105 Division of Nephrology, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland.,Division of Transplantation, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland. 960279 author Chebib Fouad T Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota. author Morita Akio 0000-0002-2497-5772 Department of Neurological Surgery, Nippon Medical School, Tokyo, Japan. author Nozaki Kazuhiko Department of Neurosurgery, Shiga University of Medical Science, Otsu, Japan. author Tominaga Teiji 0000-0003-3411-2900 Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan. author Bervitskiy Anatoliy V 0000-0001-9034-2212 The "Federal Centre of Neurosurgery" of the Ministry of Health of the Russian Federation Novosibirsk, Novosibirsk Region, Novosibirsk, Russia. author Rzaev Jamil 0000-0002-1209-8960 The "Federal Centre of Neurosurgery" of the Ministry of Health of the Russian Federation Novosibirsk, Novosibirsk Region, Novosibirsk, Russia. author Schaller Karl Lothard Division of Neurosurgery, Department of Clinical Neurosciences, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland. 658606 Département des neurosciences cliniques (OTONO) author Bijlenga Philippe Alexandre Pierre 0000-0002-3586-2757 Division of Neurosurgery, Department of Clinical Neurosciences, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland. 104899 Département des neurosciences cliniques (OTONO) e466-e475 10.34067/kid.0000000000000092 36961086 2641-7650 PMC10278849 https://journals.lww.com/10.34067/KID.0000000000000092 Key Points: <li>IAs location distribution in patients with ADPKD differ from the ones in non-ADPKD patients</li> <li>IAs in patients with ADPKD are more commonly located in the anterior circulation and in large caliber arteries</li> <li>Because of IA multiplicity and singular IA distribution, patients with ADPKD represent a special population who need to be closely followed</li> Background: Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic condition associated with intracranial aneurysms (IAs). The associated pathophysiology remains unknown, but an association with wall shear stress is suspected. Cerebral arterial location is the principal factor influencing IA natural history. This study aims to compare IA location-specific distribution between ADPKD and non-ADPKD patients. Methods: The ADPKD group comprised data from a systematic review of the literature (2016–2020, N=7) and three cohorts: integrated biomedical informatics for the management of cerebral aneurysms, Novosibirsk, and Unruptured Cerebral Aneurysms Study. The non-ADPKD group was formed from the integrated biomedical informatics for the management of cerebral aneurysms, Unruptured Cerebral Aneurysms Study, International Stroke Genetics Consortium, and the Finnish cohort from the literature. Patients and IAs characteristics were compared between ADPKD and non-ADPKD groups, and a meta-analysis for IA locations was performed. Results: A total of 1184 IAs from patients with ADPKD were compared with 21,040 IAs from non-ADPKD patients. In total, 78.6% of patients with ADPKD had hypertension versus 39.2% of non-ADPKD patients. A total of 32.4% of patients with ADPKD were smokers versus 31.5% of non-ADPKD patients. In total, 30.1% of patients with ADPKD had a positive family history for IA versus 15.8% of the non-ADPKD patients. Patients with ADPKD showed a higher rate of IA multiplicity (33.2% versus 23.1%). IAs from patients with ADPKD showed a significant predominance across the internal carotid and middle cerebral arteries. Posterior communicating IAs were more frequently found in the non-ADPKD group. The meta-analysis confirmed a predominance of IAs in the patients with ADPKD across large caliber arteries (odds ratio [95% confidence interval]: internal carotid artery: 1.90 [1.10 to 3.29]; middle cerebral artery: 1.18 [1.02–1.36]). Small diameter arteries, such as the posterior communicating, were observed more in non-ADPKD patients (0.21 [0.11–0.88]). Conclusion: This analysis shows that IAs diagnosed in patients with ADPKD are more often localized in large caliber arteries from the anterior circulation in comparison with IAs in non-ADPKD patients. It shows that primary cilia driven wall shear stress vessel remodeling to be more critical in cerebral anterior circulation large caliber arteries. Trial registration: ClinicalTrials.gov <a href="http://clinicaltrials.gov/show/NCT02848495" rel="noopener noreferrer" target="_blank">NCT02848495</a>. Humans Intracranial Aneurysm / complications Intracranial Aneurysm / epidemiology Magnetic Resonance Angiography Patients Polycystic Kidney, Autosomal Dominant / complications Polycystic Kidney, Autosomal Dominant / epidemiology Risk Factors Dewey 616.8 Dewey 616.07 Dewey 616 Dewey 617 CIHR European Commission @neurIST FP6-IST-2004-027,703 European Commission Early recognition of intracranial aneurysms to PRevent aneurYSMal subarachnoid hemorrhage 852173 PRYSM EU H2020 Dutch Heart Foundation ERASE CVON2015-08 61 Département des neurosciences cliniques 226 137 Département de pathologie et immunologie 21F 56 Département de médecine 221 57 Département de chirurgie 222 false 513 Groupe Schaller Karl Lothard (neurochirurgie) 851 397 Connexines et pathologies cardiovasculaires 665 Kidney360 4 4 5b41a0ec-9d2e-4265-835b-b5f7e79ee77b Article (Published version) Public characteristics_and_distribution_of.pdf 846945 application/pdf CC BY-4.0 60d0620738c79b985550c9703bef65e9685e2d23385b6e276b18d15069e847d6 57f1947c-fd95-40bb-bb87-6440ffced505 Appendix Public kn9_2023_02_19_haemmerli_1_sdc1.pdf 414561 application/pdf 8e4f66649356f6c1a523bcec4fcb09928f02ff83a1bdd06f1a8d14a54a4fd2e3 openAccess Faculté de médecine / Section de médecine clinique / Département des neurosciences cliniques Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine clinique / Département de chirurgie

Title	Published in	Year	Views	Downloads

Characteristics and Distribution of Intracranial Aneurysms in Patients with Autosomal Dominant Polycystic Kidney Disease Compared with the General Population: A Meta-Analysis	Kidney360	2023	44	40
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