Understanding the glycome: an interactive view of glycosylation from glycocompositions to glycoepitopes

Article Article scientifique Article Understanding the glycome: an interactive view of glycosylation from glycocompositions to glycoepitopes eng 2018 author Alocci Davide 814259 author Ghraichy Marie 820200 author Barletta Elena 860159 author Gastaldello Alessandra 811139 author Mariethoz Julien 0000-0001-8974-4417 712308 author Lisacek Frédérique 0000-0002-0948-4537 639315 349-362 10.1093/glycob/cwy019 29518231 0959-6658 https://academic.oup.com/glycob/article/28/6/349/4923253 Nowadays, due to the advance of experimental techniques in glycomics, large collections of glycan profiles are regularly published. The rapid growth of available glycan data accentuates the lack of innovative tools for visualizing and exploring large amount of information. Scientists resort to using general-purpose spreadsheet applications to create ad hoc data visualization. Thus, results end up being encoded in publication images and text, while valuable curated data is stored in files as supplementary information. To tackle this problem, we have built an interactive pipeline composed with three tools: Glynsight, EpitopeXtractor and Glydin'. Glycan profile data can be imported in Glynsight, which generates a custom interactive glycan profile. Several profiles can be compared and glycan composition is integrated with structural data stored in databases. Glycan structures of interest can then be sent to EpitopeXtractor to perform a glycoepitope extraction. EpitopeXtractor results can be superimposed on the Glydin' glycoepitope network. The network visualization allows fast detection of clusters of glycoepitopes and discovery of potential new targets. Each of these tools is standalone or can be used in conjunction with the others, depending on the data and the specific interest of the user. All the tools composing this pipeline are part of the Glycomics@ExPASy initiative and are available at https://www.expasy.org/glycomics. Dewey 025.063 Dewey 570 13 Centre universitaire d'informatique 0D3 30 Section de biologie 16 32 Département d'informatique 18 false 1316 Proteome informatics Group Glycobiology 28 6 826f405b-cf37-427d-aa01-67115b2a759f Article (Published version) Restricted cwy019final.pdf 1118381 application/pdf restrictedAccess Centres et instituts / Centre universitaire d'informatique Faculté des sciences / Section de biologie Faculté des sciences / Département d'informatique

Title	Published in	Year	Views	Downloads

Understanding the glycome: an interactive view of glycosylation from glycocompositions to glycoepitopes	Glycobiology	2018	254	1
Bioinformatics tools for studying glycan-protein interactions		2016	101	10

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Ghraichy, Marie