Spatial reference learning deficits in absence of dysfunctional working memory in the TgF344-AD rat model of Alzheimer's disease

Article Article scientifique Article Spatial reference learning deficits in absence of dysfunctional working memory in the TgF344-AD rat model of Alzheimer's disease eng 2020 author Tournier Benjamin 705309 author Barca Cristina 692170 author Fall Aïda 0000-0003-0841-7815 746218 author Gloria Yesica 896357 author Meyer Léa 818031 author Ceyzeriat Kelly 910236 author Millet Philippe 0000-0002-5803-0478 668343 e12712 10.1111/gbb.12712 33150709 1601-183X Alzheimer's disease (AD) is characterized by cognitive disorders and alterations of behavioral traits such as anhedonia and anxiety. Contribution of nonphysiological forms of amyloid and tau peptides to the onset of neurological dysfunctions remains unclear because most preclinical models only present one of those pathological AD‐related biomarkers. A more recently developed model, the TgF344‐AD rat has the advantage of overexpressing amyloid and naturally developing tauopathy, thus making it close to human familial forms of AD. We showed the presence of a learning dysfunction in a reference memory test, without spatial working memory impairment but with an increase in anxiety levels and a decrease in motivation to participate in the test. In the sucrose preference test, TgF344‐AD rats did not show signs of anhedonia but did not increase the volume of liquid consumed when the water was replaced by sucrose solution. These behavioral phenomena were observed at an age when tau accumulation are absent, and where amyloid deposits are predominant in the hippocampus and the entorhinal cortex. Within the hippocampus itself, amyloid accumulation is heterogenous between the subiculum, the dorsal hippocampus and the ventral hippocampus. Thus, our data demonstrated heterogeneity in the appearance of various behavioral and neurochemical markers in the TgF344‐AD rat. This multivariate analysis will therefore make it possible to define the stage of the pathology, to measure its evolution and the effects of future therapeutic treatments. Alzheimer's disease Anxiety Dopamine Spatial reference memory Spatial working memory Dewey 616.0757 Dewey 616.89 60 Département de psychiatrie 225 62 Département de radiologie et informatique médicale 227 false 1221 Neuroimagerie moléculaire en psychiatrie 983 Genes, Brain and Behavior 576767f7-0711-4f86-bbe5-d3f61b4b1e14 Article (Published version) Restricted Tournier-2020_GBB.pdf 1539155 application/pdf restrictedAccess Faculté de médecine / Section de médecine clinique / Département de psychiatrie Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale

Title	Published in	Access level	OA Policy	Year	Views	Downloads

Spatial reference learning deficits in absence of dysfunctional working memory in the TgF344-AD rat model of Alzheimer's disease	Genes, Brain and Behavior			2020	362	2

Archive ouverte UNIGE

Meyer, Léa