Theranostic nanoparticles for detection and targeted therapy of prostate cancer and lymph node metastases

Diplôme Thèse Theranostic nanoparticles for detection and targeted therapy of prostate cancer and lymph node metastases eng 2018-10-18 author Maudens Stella-Saphira 811058 director Jordan Olivier 0000-0003-3752-2198 133859 director Borchard Gerrit 635281 10.13097/archive-ouverte/unige:125025 urn:nbn:ch:unige-1250258 Sc. 5273 The aim of this thesis was to explore iron oxide nanoparticles (IONPs) for ultimate detection and co-treatment of early prostate cancer (PC) lymph node metastases. IONPs previously optimized as a theranostic tool for the combined use in MRI and magnetic hyperthermia were functionalized with an RNA aptamer or a small molecule, both actively targeting the prostate-specific membrane antigen (PSMA). Functionalized IONPs were developed to meet the requirements for lymphatic targeting and specific binding to PSMA-expressing PC cells while preserving high MRI relaxivity and heating properties. In a second project, we designed and tested an in situ forming implant entrapping IONPs as a heating source for magnetic hyperthermia with intended application in localized PC. Besides appropriate syringeability and implant formation upon injection, we confirmed homogeneous intrinsic radiopacity in micro-CT in vivo. When applying magnetic field strengths and frequencies eligible for use in humans, the implant reached the hyperthermia target temperature of 48 °C. Iron oxide nanoparticles Aptamer ACUPA Active targeting Prostate-specific membrane antigen Prostate cancer lymph node metastases Theranostics MRI conrast agent Magnetic hyperthermia In situ forming implant Dewey 615 Autre MagnetoTheranostics, Nano-Tera.ch 31 Section des sciences pharmaceutiques 17 false 879 Biopharmacie 527354e7-edf0-4442-8724-7c5aa05240e7 Thesis Public Thesis_S_Maudens.pdf 18675172 application/pdf Private 2020-04-15 f2cfa5e1a2cfcad867b8d445dca0fef56260ec5c91ac19f27ad1c4bce1fe658d openAccess Faculté des sciences / Section des sciences pharmaceutiques

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Theranostic nanoparticles for detection and targeted therapy of prostate cancer and lymph node metastases				2018	405	290

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Maudens, Stella-Saphira