Reduced aerobic capacity in children with multisystem inflammatory syndrome in children (MIS-C) after PICU admission : a retrospective cohort study, 2020

Article Article scientifique Article Reduced aerobic capacity in children with multisystem inflammatory syndrome in children (MIS-C) after PICU admission : a retrospective cohort study, 2020–2022 eng 2025-10-21 author Maggio Albane Bertha 0000-0002-9110-4467 Health and movement consultation, Division of Paediatric Specialties, Department of paediatrics, gynaecology and obstetrics, Geneva University Hospital and University of Geneva, Boulevard de la Cluse 26, Geneva 14, 1211, Switzerland. 649221 Département de Pédiatrie, Gynécologie et Obstétrique (PETRI) author Palomo Sofia Paediatric Intensive Care Unit, Department of Paediatrics, Gynaecology and Obstetrics, Geneva University Hospital, University of Geneva, Rue Willy-Donzé 6,, Geneva 14, 1211 , Switzerland. 807349 author Joye Raphaël Paediatric Cardiology Unit, Department of paediatrics, gynaecology and obstetrics, Geneva University Hospital and University of Geneva, Rue Willy-Donzé 6, Geneva 14, 1211, Switzerland. 678463 author Huguet Héléna Clinical Research and Epidemiology Unit, Clinical Investigation Centre, Montpellier University Hospital, INSERM-CIC, University of Montpellier, Montpellier, 1411, France. author Polito Angelo Paediatric Intensive Care Unit, Department of Paediatrics, Gynaecology and Obstetrics, Geneva University Hospital, University of Geneva, Rue Willy-Donzé 6,, Geneva 14, 1211 , Switzerland. 891320 Département de Pédiatrie, Gynécologie et Obstétrique (PETRI) author Gavotto Arthur 0000-0001-6485-7634 PhyMedExp, CNRS, INSERM, University of Montpellier, 371 Avenue du Doyen Giraud, Montpellier, 34295, France. a-gavotto@chu-montpellier.fr.,Department of Neonatal Medicine and Paediatric Intensive Care, Arnaud de Villeneuve Hospital,, Montpellier University Hospital Centre, France, 371 Avenue du Doyen Giraud, Montpellier, 34295, France. a-gavotto@chu-montpellier.fr. 835 10.1186/s12887-025-06236-w 41120895 1471-2431 PMC12539095 Objective: This study aimed to evaluate aerobic capacity in children and adolescents following a diagnosis of Multisystem Inflammatory Syndrome in Children (MIS-C) compared to healthy matched controls. Design: Prospective cohort study. Setting: Quaternary Pediatric intensive care unit and Pediatric cardiology unit. Participants: 14 children diagnosed with MIS-C. Interventions: None. Measurements: Cardiopulmonary fitness parameters at the time of post-Pediatric intensive care unit follow-up (mean 3.6 months) such as maximum oxygen uptake (VO2max ) and the first ventilatory anaerobic threshold (VAT), as a marker of muscular deconditioning. Main results: A total of 14 patients (12 boys) with a confirmed diagnosis of MIS-C and 70 healthy children were included. The median age was 13.2 years (range 10.7-13.6 years). All participants had a normal echocardiogram and normal lung function at the time of cardiopulmonary exercise test. As measured by VO2max Z-score, exercise capacity was significantly lower in the MIS-C group compared to healthy controls (median-0.91 vs 0.13, p < 0.01), and a significantly higher proportion of children in the MIS-C group had impaired aerobic capacity (VO2max Z-score<-1.64) compared to controls (29% vs. 3%, p < 0.01). The VAT was also significantly lower in the MIS-C group with a higher proportion of children with an impaired VAT (VAT Z-score<-1.64) compared to controls (43% vs. 3%, p = 0.03). Impaired aerobic capacity in the MIS-C group was associated with higher BMI, higher PELOD 2 score and lower platelet count at the PICU admission, and lower hemoglobin level at the cardiopulmonary exercise test time. Conclusions: This study suggests that children with MIS-C experience significant reductions in aerobic capacity compared to healthy controls, primarily due to muscular deconditioning. These findings highlight the importance of considering post-ICU consultations and implementing strategies to address physical deconditioning in this population. Cardiopulmonary exercise test MIS-C Muscular deconditioning VO2 Dewey 618 58 Département de pédiatrie, gynécologie et obstétrique 223 false 179 L'hypertension pulmonaire (pédiatrie) 228 BMC pediatrics 25 1 feebe53e-1cc2-4192-9053-56ffaeecb756 Article (Published version) Public Article_scientifique_from_unpaywall.pdf 1206636 application/pdf CC BY-NC-ND-4.0 968cb5675c1b7c667f2d5ca2b6e04efd2bfb1eada16951931ce8df92857de19f openAccess Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique

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Reduced aerobic capacity in children with multisystem inflammatory syndrome in children (MIS-C) after PICU admission : a retrospective cohort study, 2020–2022	BMC pediatrics			2025	4	23

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