A randomized controlled trial investigating the effect of liraglutide on self-reported liking and neural responses to food stimuli in participants with obesity

Article Article scientifique Article A randomized controlled trial investigating the effect of liraglutide on self-reported liking and neural responses to food stimuli in participants with obesity eng 2023-08-25 2023-08-25 author Coppin Géraldine 0000-0002-7848-3298 642559 author Munoz Tord David 0000-0001-7954-8295 838479 author Pool Eva 699771 Section de psychologie (PSICO) author Locatelli Loïc 597228 author Achaibou Amal 643549 author Erdemli Asli 0000-0003-4970-4028 820355 Services communs du CISA (EMCO) author Leon Perez Laura 806053 Section des sciences de l'éducation (SSED) author Wuensch Lavinia 0000-0002-7965-6277 778098 Services communs du CISA (EMCO) author Cereghetti Donato 729645 author Golay Alain 27404 Décanat et administration de la faculté de médecine (ADMED) author Sander David 558712 Section de psychologie (PSICO) author Pataky Zoltan 0000-0002-8720-3833 105295 Département de médecine (DEMED) 1224-1231 10.1038/s41366-023-01370-w 37626125 0307-0565 https://www.nature.com/articles/s41366-023-01370-w Background/Objectives Obesity is a complex condition and the mechanisms involved in weight gain and loss are not fully understood. Liraglutide, a GLP-1 receptor agonist, has been demonstrated to successfully promote weight loss in patients with obesity (OB). Yet, it is unclear whether the observed weight loss is driven by an alteration of food liking. Here we investigated the effects of liraglutide on food liking and the cerebral correlates of liking in OB. Subjects/Methods This study was a randomized, single-center, double-blind, placebo-controlled, parallel group, prospective clinical trial. 73 participants with OB and without diabetes following a multidisciplinary weight loss program, were randomly assigned (1:1) to receive liraglutide 3.0 mg (37.40 ± 11.18 years old, BMI = 35.89 ± 3.01 kg) or a placebo (40.04 ± 14.10 years old, BMI = 34.88 ± 2.87 kg) subcutaneously once daily for 16 weeks. Interventions/Methods We investigated liking during food consumption. Participants reported their hedonic experience while consuming a high-calorie food (milkshake) and a tasteless solution. The solutions were administered inside the scanner with a Magnetic Resonance Imaging (MRI)-compatible gustometer to assess neural responses during consumption. The same procedure was repeated during the pre- and post-intervention sessions. Results None of the effects involving the intervention factor reached significance when comparing liking between the pre- and post-intervention sessions or groups. Liking during food reward consumption was associated with the activation of the ventromedial prefrontal cortex (vmPFC) and the amygdala. The liraglutide group lost more weight (BMI post-pre = −3.19 ± 1.28 kg/m 2 ) than the placebo group (BMI post-pre = −0.60 ± 1.26 kg/m 2 ). Conclusions These results suggest that liraglutide leads to weight loss without self-report or neural evidence supporting a concomitant reduction of food liking in participants with OB. Obesity Weight gain and loss Liraglutide Dewey 128.37 Dewey 616 Dewey 150 Swiss National Science Foundation The impact of altered cognitive and affective abilities on food intake and obesity: An online health intervention 181094 CH Careers Swiss National Science Foundation Individual differences in emotional learning underpinning vulnerabilities to compulsive reward-seeking behaviors 193120 CH Careers 56 Département de médecine 221 108 Section de psychologie 71 15 Centre interfacultaire en sciences affectives 0D8 false 1392 Pied diabétique 1043 334 Education thérapeutique du patient, diabète et obésité 600 https://github.com/munoztd0/Mouthpiecegusto/tree/main/preprocessing https://github.com/evapool/GLP1_Pleasure International journal of obesity 47 12 70a5f29b-8059-41ca-b04d-881561e4601d Article (Published version) Public Article-scientifique-from-unpaywall.pdf 1095925 application/pdf CC BY-4.0 6779ea820d8586a6cf745886c5aca062e7f2f78d68f8a19c9c9aa0b65a4aa37f 8e34ec1c-c19a-4cdd-8137-0b358e482f0e Supplemental data Public 41366_2023_1370_MOESM1_ESM.pdf 527864 application/pdf a8a91d210301099dd2db43df03d5f1054521e6abebc48a4e19c08b3bfd76f10e openAccess Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de psychologie et des sciences de l'éducation / Section de psychologie Centres et instituts / Centre interfacultaire en sciences affectives

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A randomized controlled trial investigating the effect of liraglutide on self-reported liking and neural responses to food stimuli in participants with obesity	International journal of obesity			2023	146	243

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Leon Perez, Laura