Electrophysiological and behavioral correlates of cannabis use disorder

Article Article scientifique Article Electrophysiological and behavioral correlates of cannabis use disorder eng 2022-06-13 2022-12 author Andriot Théo 0000-0001-9169-6047 850896 author Ohnmacht Patrick 803269 author Vuilleumier Patrik 0000-0002-8198-9214 134853 Département de neurosciences fondamentales (NEUFO) author Thorens Gabriel 88882 Département de psychiatrie (PSYAT) author Khazaal Yasser 0000-0002-8549-6599 668423 author Ginovart Nathalie 0000-0003-1684-6599 637504 Département de psychiatrie (PSYAT) author Ros Tomas 0000-0001-6952-0459 771389 Centre d'imagerie bio-médicale (CIBM) 1421-1431 10.3758/s13415-022-01016-w 35698004 1530-7026 PMC9622528 https://link.springer.com/10.3758/s13415-022-01016-w Current research indicates deficits in cognitive function together with widespread changes in brain activity following long-term cannabis use. In particular, cannabis use has been associated with excessive spectral power of the alpha rhythm (8–12 Hz), which is also known to be modulated during attentional states. Recent neuroimaging studies have linked heavy cannabis use with structural and metabolic changes in the brain; however, the functional consequences of these changes are still not fully characterized. This study investigated the electrophysiological and behavioral correlates of cannabis dependence by comparing patients with a cannabis use disorder (CUD; N = 24) with cannabis nonuser controls (N = 24), using resting state electroencephalogram (EEG) source-imaging. In addition to evaluating mean differences between groups, we also explored whether particular EEG patterns were associated with individual cognitive-behavioral measures. First, we replicated historical findings of elevated levels of (relative) alpha rhythm in CUD patients compared with controls and located these abnormalities to mainly prefrontal cortical regions. Importantly, we observed a significant negative correlation between alpha spectral power in several cortical regions and individual attentional performance in the Go/NoGo task. Because such relationship was absent in the nonuser control group, our results suggest that reduced prefrontal cortical activation (indexed by increased relative alpha power) could be partly responsible for the reported cognitive impairments in CUD. Our findings support the use of electroencephalography as a noninvasive and cost-effective tool for biomarker discovery in substance abuse and have the potential of directly informing future intervention strategies. Alpha oscillation Attentional performance Cannabis use disorder Cortical activation Electroencephalography Dewey 616.89 Dewey 616.8 Swiss National Science Foundation Striatal presynaptic dopamine function in impulsivity: implications for understanding the neurobiological underpinnings of addictive disorders 179373 CH Projects 60 Département de psychiatrie 225 53 Département de neurosciences fondamentales 21A false 1250 Imagerie de la transmission dopaminergique dans les troubles addictifs 989 428 Mécanismes cérébraux du comportement et des fonctions cognitives 701 Cognitive, affective & behavioral neuroscience 22 6 8c6e98a7-7208-4fbe-916a-d3b220bfd95b Article (Published version) Public Article-scientifique-from-crossref.pdf 1215364 application/pdf CC BY-4.0 f35ac2aef71d6a6e069903c47fa233ea41d5b8fd89cc702551c88fd80d33afda openAccess Faculté de médecine / Section de médecine clinique / Département de psychiatrie Faculté de médecine / Section de médecine fondamentale / Département de neurosciences fondamentales

Title	Published in	Year	Views	Downloads

Electrophysiological and behavioral correlates of cannabis use disorder	Cognitive, affective & behavioral neuroscience	2022	140	232
Consommation d'alcool chez les les jeunes adultes et biais d'attention sélective		2016	230	21

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Ohnmacht, Patrick