Localized Non-melanoma Skin Cancer : Risk Factors of Post-surgical Relapse and Role of Postoperative Radiotherapy

Article Article scientifique Revue de la littérature Localized Non-melanoma Skin Cancer : Risk Factors of Post-surgical Relapse and Role of Postoperative Radiotherapy eng 2020-10-09 2020-12 author Caparrotti Francesca Department of Radiation Oncology, Geneva University Hospital, CH-1211, Geneva 14, Switzerland. 824984 author Troussier Idriss Department of Radiation Oncology, Geneva University Hospital, CH-1211, Geneva 14, Switzerland. author Ali Abdirahman Faculty of Medicine, Geneva University, Geneva, Switzerland. 800181 author Zilli Thomas 0000-0002-4784-9883 Department of Radiation Oncology, Geneva University Hospital, CH-1211, Geneva 14, Switzerland. Thomas.Zilli@hcuge.ch.,Faculty of Medicine, Geneva University, Geneva, Switzerland. Thomas.Zilli@hcuge.ch. 791833 Département de radiologie et informatique médicale (RADIO) 97 10.1007/s11864-020-00792-2 33034759 1534-6277 PMC7546974 https://link.springer.com/10.1007/s11864-020-00792-2 The mainstay treatment of localized non-melanoma skin cancer (NMSC) is surgical excision or Mohs surgery. However, approximately 5% of patients with NMSC harbor high-risk clinicopathologic features for loco-regional recurrence, and distant metastasis. Prognostic factors such as close or positive margins, tumor size ≥ 2 cm, poor tumor differentiation, perineural invasion, depth of invasion, and immunosuppression have all been associated with increased loco-regional recurrence and impaired survival rates. In these patients more aggressive treatments are needed and radiotherapy (RT) is often discussed as adjuvant therapy after surgical resection. Due to the retrospective setting and the heterogeneity of the available studies, indications for adjuvant RT in patients with localized resected NMSC harboring high-risk features remain debated. Studies highlighting the limitations of our current understanding of the independent prognosis of each risk factor are needed to better define the role of adjuvant RT on outcome of localized NMSC and standardize its indications in the clinical setting. Adjuvant Basal cell carcinoma Non-melanoma skin cancer Postoperative Radiotherapy Squamous cell carcinoma Dewey 616.0757 62 Département de radiologie et informatique médicale 227 false Current treatment options in oncology 21 12 14821532-5ff0-4501-b2c4-29a449fa711a Article (Published version) Public Article_scientifique_from_crossref.pdf 360554 application/pdf CC BY-4.0 8d9ba16733451382f5a6208ed3d76859493b9c5375f1fd2b2f0e278445a22991 openAccess Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale

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Localized Non-melanoma Skin Cancer : Risk Factors of Post-surgical Relapse and Role of Postoperative Radiotherapy	Current treatment options in oncology			2020	3	3

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Ali, Abdirahman