Genomic Instability Is an Early Event in Aluminium-Induced Tumorigenesis

Article Article scientifique Article Genomic Instability Is an Early Event in Aluminium-Induced Tumorigenesis eng 2020 author Mandriota Stefano Jacopo 29730 author Tenan Mirna 133892 author Nicolle Adeline 797175 author Jankowska Julia D author Ferrari Paolo author Tille Jean-Christophe 87627 author Durin Mary-Anne author Green Catherine M author Tabruyn Sebastien author Moralli Daniela author Sappino André-Pascal 9332 10.3390/ijms21239332 33297592 1661-6596 Genomic instability is generally considered as a hallmark of tumorigenesis and a prerequisite condition for malignant transformation. Aluminium salts are suspected environmental carcinogens that transform mammary epithelial cells in vitro through unknown mechanisms. We report here that long-term culture in the presence of aluminium chloride (AlCl3) enables HC11 normal mouse mammary epithelial cells to form tumours and metastases when injected into the syngeneic and immunocompetent BALB/cByJ strain. We demonstrate that AlCl3 rapidly increases chromosomal structural abnormalities in mammary epithelial cells, while we failed to detect direct modulation of specific mRNA pathways. Our observations provide evidence that clastogenic activity-a well-recognized inducer of genomic instability-might account in part for the transforming abilities of aluminium in mammary epithelial cells. Aluminium Breast cancer Carcinogenesis Genomic instability Clastogens Dewey 616.07 137 Département de pathologie et immunologie 21F false 391 Métastases du foie 657 International Journal of Molecular Sciences 21 23 86fcf6a6-3802-4a44-b91f-0f97f30b89dc Article (Published version) Public Genomic.pdf 12537978 application/pdf CC BY openAccess Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie

Title	Published in	Access level	OA Policy	Year	Views	Downloads

Genomic Instability Is an Early Event in Aluminium-Induced Tumorigenesis	International Journal of Molecular Sciences			2020	288	229

Archive ouverte UNIGE

Nicolle, Adeline