Does telaprevir possess a direct antidiabetic effect?

Article Article scientifique Rapport de cas Does telaprevir possess a direct antidiabetic effect? eng 2014 author Tallon De Lara Paulino 797231 author Himschoot Thomas 795251 author Frossard Jean-Louis 35038 author Negro Francesco 96509 967-969 10.1111/liv.12440 24329983 1478-3223 Hepatitis C virus (HCV) induces insulin resistance, which improves upon viral clearance. Telaprevir is a protease inhibitor effective against HCV genotype 1. We reported a case, whose history suggests that telaprevir may induce some antidiabetic effect independently of its suppression of HCV. A 56-year-old woman with obesity, type 2 diabetes treated with sitagliptin and metformin, and HCV-related cirrhosis was given triple therapy with pegylated interferon-alpha, ribavirin and telaprevir. After 2 weeks of treatment, HCV RNA was no longer detectable but the patient described a pronounced drop in the capillary glucose levels and episodes of hypoglycaemia that compelled her to stop all antidiabetic treatment. One month after stopping telaprevir, she had to resume her antidiabetic treatment, despite a persisting virological response. Despite reaching a sustained virological response, her diabetes progressed. Although the suppression of HCV replication may have played a role in reducing glucose intolerance, the fact that this patient resumed her prior antidiabetic treatment upon completing the telaprevir treatment, while still aviremic, suggests that telaprevir may have an additional antidiabetic effect. Further evidence about the possible role and mechanisms of telaprevir as antidiabetic agent is warranted. Dewey 616 Dewey 616.07 137 Département de pathologie et immunologie 21F 56 Département de médecine 221 false 297 Etudes et traitement de l'hépatite C et B 554 335 Pancréatite aiguë 601 Liver international 34 6 74e811fc-ac86-49c2-8671-a76d2369dc81 Article (Accepted version) Restricted Negro F. Liver Int 2014, 34(6) 967.pdf 189843 application/pdf restrictedAccess Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie Faculté de médecine / Section de médecine clinique / Département de médecine

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Does telaprevir possess a direct antidiabetic effect?	Liver international			2014	623	0

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Himschoot, Thomas