Longitudinal functional brain connectivity maturation in premature newborn infants: Modulatory influence of early music enrichment

Article Article scientifique Article Longitudinal functional brain connectivity maturation in premature newborn infants: Modulatory influence of early music enrichment eng 2024-11-18 2024-11-18 author Van Der Veek Annemijn 794590 author Loukas Serafeim 833303 author Lordier Lara author Alves Sa De Almeida Joana Rita 863867 author Filippa Manuela 0000-0002-1310-8008 890536 Section de psychologie (PSICO) author Lazeyras François 512748 author Van De Ville Dimitri 0000-0002-2879-3861 638484 Département de radiologie et informatique médicale (RADIO) author Hüppi Petra Susan 133591 Département de Pédiatrie, Gynécologie et Obstétrique (PETRI) 1-18 10.1162/imag_a_00373 40041298 2837-6056 PMC11873764 https://direct.mit.edu/imag/article/doi/10.1162/imag_a_00373/125035/Longitudinal-functional-brain-connectivity <p>Premature birth affects brain maturation, illustrated by altered brain functional connectivity at term equivalent age (TEA) and alters neurobehavioral outcome. To correct early developmental differences and improve neurological outcome, music during the neonatal intensive care unit (NICU) stay has been proposed as an auditory enrichment with modulatory effects on functional and structural brain development, but longitudinal effects of such interventions have not been studied so far. We longitudinally investigated resting-state functional connectivity (RS-FC) maturation in preterm infants (n = 43). Data-driven Independent Component Analyses (ICA) were performed on scans obtained at 33- and 40-week gestational age (GA), determining the presence of distinct resting-state networks (RSNs). Connectome analysis “accordance measure” quantitively examined the RS-FC both at 33- and 40-week GA. Further comparing the internetwork RS-FC at 33- and 40-week GA provided a circuitry of interest (COI) for significant maturational changes in which the effects on the RS-FC of a music intervention were tested. The connectome analyses resulted in a COI of RS-FC connections significantly maturing from 33 to 40 weeks GA, namely between the thalamic/brainstem and prefrontal–limbic, salience, sensorimotor, auditory, and prefrontal cortical networks; between the prefrontal–limbic and cerebellar, visual and left hemispheric precuneus networks; between the salience and visual, and cerebellar networks; and between the sensorimotor and auditory, and posterior cingulate/precuneus networks. The infants exposed to music exhibited significantly increased maturation in RS-FC between the thalamic/brainstem and salience networks, compared with controls. This study exemplifies that preterm infant RS-FC maturation is modulated through NICU music exposure, highlighting the importance of environmental enrichment for neurodevelopment in premature newborns.</p> Connectome analyses Longitudinal maturation Music intervention Prematurity Resting-state fMRI Dewey 616.0757 Dewey 150 Dewey 618 European Commission Data-driven models for Progression Of Neurological Disease 666992 EuroPOND EU H2020 Swiss National Science Foundation Development of Emotion and Cognition in Preterm Born Cohorts: Neurostructural and Neurofunctional Correlates from Birth to Early Adolescence 135817 CH Projects Swiss National Science Foundation Building the path to resilience in preterm infants: a neuroimaging investigation of the impact of multisensory and neurocognitive interventions 163084 CH Projects 108 Section de psychologie 71 62 Département de radiologie et informatique médicale 227 58 Département de pédiatrie, gynécologie et obstétrique 223 false 1241 Affective sciences 594 Neuroscience de l'émotion et dynamiques affectives (NEAD) 552 Traitement d'images médicales 893 284 Groupe Lazeyras Francois (IRM fonctionnelle et métabolique) 539 150 L'imagerie cérébrale 184 523 CIBM 863 Imaging neuroscience 2 c791a25e-5868-4144-818a-22d824b26e16 Article (Published version) Public imag_a_00373.pdf 5841574 application/pdf 865953c5a418eccf816731737d7a669a823f4ba615e810f2174ca108240cac66 openAccess Faculté de psychologie et des sciences de l'éducation / Section de psychologie Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique

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Longitudinal functional brain connectivity maturation in premature newborn infants: Modulatory influence of early music enrichment	Imaging neuroscience			2024	161	128

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Van Der Veek, Annemijn