Adding a new separation dimension to MS and LC–MS: What is the utility of ion mobility spectrometry?

Article Article scientifique Revue de la littérature Adding a new separation dimension to MS and LC–MS: What is the utility of ion mobility spectrometry? eng 2018 author D'Atri Valentina 846921 author Causson Tim author Hernandez-Alba Oscar author Mutabazi Aline 783531 author Veuthey Jean-Luc 22317 author Cianferani Sarah author Guillarme Davy 623637 20-67 10.1002/jssc.201700919 29024509 1615-9306 Ion mobility spectrometry is an analytical technique known for more than 100 years, which entails separating ions in the gas phase based on their size, shape, and charge. While ion mobility spectrometry alone can be useful for some applications (mostly security analysis for detecting certain classes of narcotics and explosives), it becomes even more powerful in combination with mass spectrometry and high-performance liquid chromatography. Indeed, the limited resolving power of ion mobility spectrometry alone can be tackled when combining this analytical strategy with mass spectrometry or liquid chromatography with mass spectrometry. Over the last few years,the hyphenation of ion mobility spectrometry to mass spectrometry or liquid chromatography withmass spectrometry has attracted more and more interest, with significant progresses in both technical advances and pioneering applications. This review describes the theoretical background, available technologies, and future capabilities of these techniques. It also highlights a wide range of applications, from small molecules (natural products, metabolites, glycans, lipids) to large biomolecules (proteins, protein complexes, biopharmaceuticals, oligonucleotides). Biopharmaceuticals Collision cross-section values Ion mobility spectrometry Metabolomics Oligonucleotides Dewey 615 31 Section des sciences pharmaceutiques 17 false 881 Sciences analytiques Journal of Separation Science 41 00d74c57-ac6c-4817-8ab2-90c77f87042f Article (Published version) Restricted 2018_-_Adding_a_new_separation_dimension_to_MS_and_LC–MS,_JSS,_2018,_41,_20-67.pdf 3008950 application/pdf restrictedAccess Faculté des sciences / Section des sciences pharmaceutiques

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Adding a new separation dimension to MS and LC–MS: What is the utility of ion mobility spectrometry?	Journal of Separation Science			2018	614	5

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Mutabazi, Aline