A subpopulation of cortical VIP-expressing interneurons with highly dynamic spines

Article Article scientifique Article A subpopulation of cortical VIP-expressing interneurons with highly dynamic spines eng 2022-04-13 2022-04-13 author Georgiou Christina 782327 author Kechagias Vasileios 739252 author Lee Kok Sin 0000-0003-1631-8622 829040 author Brandalise Federico 0000-0002-2033-5719 910962 author Sahlender Daniela A. 0000-0002-0510-9529 author Blanc Jerome author Knott Graham 0000-0002-2956-9052 author Holtmaat Anthony 0000-0002-7577-0769 661031 352 10.1038/s42003-022-03278-z 35418660 2399-3642 PMC9008030 https://www.nature.com/articles/s42003-022-03278-z Abstract <p>Structural synaptic plasticity may underlie experience and learning-dependent changes in cortical circuits. In contrast to excitatory pyramidal neurons, insight into the structural plasticity of inhibitory neurons remains limited. Interneurons are divided into various subclasses, each with specialized functions in cortical circuits. Further knowledge of subclass-specific structural plasticity of interneurons is crucial to gaining a complete mechanistic understanding of their contribution to cortical plasticity overall. Here, we describe a subpopulation of superficial cortical multipolar interneurons expressing vasoactive intestinal peptide (VIP) with high spine densities on their dendrites located in layer (L) 1, and with the electrophysiological characteristics of bursting cells. Using longitudinal imaging in vivo, we found that the majority of the spines are highly dynamic, displaying lifetimes considerably shorter than that of spines on pyramidal neurons. Using correlative light and electron microscopy, we confirmed that these VIP spines are sites of excitatory synaptic contacts, and are morphologically distinct from other spines in L1.</p> Dewey 616.8 Swiss National Science Foundation Activity-dependent functional and structural plasticity in the somatosensory cortex in vivo 31003A_153448 CH Project funding Swiss National Science Foundation The role of paralemniscal circuits in cortical plasticity and perception 31003A_173125 CH Project funding Swiss National Science Foundation Function and structure of neuromodulatory inputs to the cerebral cortex CRSII3_154453 CH Programmes 53 Département de neurosciences fondamentales 21A 16 Centre interfacultaire de neurosciences 0D9 false 517 Les circuits neuronaux dans le néocortex des mammifères 855 Communications biology 5 1 eef7935a-8b03-4579-bde7-d440d5a4aefd Article (Published version) Public Article-scientifique-from-crossref.pdf 3785667 application/pdf CC BY-4.0 cd94ea9c-950b-4653-afc0-e8a04836c25a Supplemental data Public 42003_2022_3278_MOESM2_ESM(1).pdf 9518116 application/pdf CC BY-4.0 openAccess Faculté de médecine / Section de médecine fondamentale / Département de neurosciences fondamentales Centres et instituts / Centre interfacultaire de neurosciences

Title	Published in	Year	Views	Downloads

A subpopulation of cortical VIP-expressing interneurons with highly dynamic spines	Communications biology	2022	181	79
Long term imaging in vivo of dendritic spine dynamics on an inhibitory neuronal subclass in the mouse cerebral cortex		2016	795	0

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Georgiou, Christina