Maladie a IgG4 : l'experience genevoise

Article Article scientifique Article Maladie a IgG4 : l'experience genevoise fre 2019 author Pellet Léo 780818 author Coattrenec Yann 635051 author Moll Solange 28349 author Seebach Jorg Dieter 647894 736-741 30942972 1660-9379 IgG4-related disease is a fibroinflammatory pathology which gathers several disorders with common histological, serological and clinical features. The disease usually manifests itself as a diffuse or localized enlargement of one or several organs that reveals upon histology a dense lymphoplasmatic infiltrate with IgG4 positive plasma cells, a storiform fibrosis and obliterative phlebitis. Serum IgG4 are often but not always increased. Diagnostic criterias were published in 2011. Lesions caused by the disease might become irreversible without treatment. Currently, glucocorticoids are the first line of treatment. However, other immunosuppressants such as rituximab are sometimes used. Autoimmune Diseases Glucocorticoids/therapeutic use Humans Immunoglobulin G Immunoglobulin G4-Related Disease/diagnosis/drug therapy Plasma Cells Dewey 616 Dewey 616.07 137 Département de pathologie et immunologie 21F 56 Département de médecine 221 false 393 Analyse protéomique et Analyse génomique des maladies rénales 659 518 Cellules NK et récepteurs FcyR dans l'auto-immunité et le rejet de xénotransplantation 856 Revue médicale suisse 15 645 193890ac-964e-4c27-a16e-0e8fad84585f Article (Published version) Public Article-1.pdf 1587633 application/pdf Restricted 2019-12-03 openAccess Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie Faculté de médecine / Section de médecine clinique / Département de médecine

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Maladie a IgG4 : l'experience genevoise	Revue médicale suisse			2019	480	659

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Pellet, Léo