An Unusual Association Between Acquired Hemophilia A and Type 2 Autoimmune Pancreatitis

Article Article scientifique Rapport de cas An Unusual Association Between Acquired Hemophilia A and Type 2 Autoimmune Pancreatitis eng 2026-05-07 author Iarossi Michaël 0000-0002-8873-6340 Hôpitaux Universitaires de Genève, Service d'angiologie et hémostase, Switzerland, Geneva. 447929 author Do Cuong An Hôpitaux Universitaires de Genève, Service d'angiologie et hémostase, Switzerland, Geneva. 780219 author Frossard Jean-Louis Hôpitaux Universitaires de Genève, Service de gastroentérologie, Switzerland, Geneva. 35038 Département de médecine (DEMED) author Fontana Pierre 0000-0003-1546-0774 Hôpitaux Universitaires de Genève, Service d'angiologie et hémostase, Switzerland, Geneva. 135328 Département de médecine (DEMED) author Casini Alessandro 0000-0001-7910-933X Hôpitaux Universitaires de Genève, Service d'angiologie et hémostase, Switzerland, Geneva. 510964 Département de médecine (DEMED) 10.1055/a-2829-7111 42097159 0720-9355 Acquired hemophilia A (AHA) is a rare autoimmune bleeding disorder that can be triggered by underlying immune-mediated diseases. We report the case of a 63-year-old man who developed AHA 1 month after undergoing pancreaticoduodenectomy for a pseudotumoral lesion, which was histologically consistent with type 2 autoimmune pancreatitis (AIP). The patient presented with gastrointestinal bleeding, a markedly prolonged activated partial thromboplastin time, reduced factor VIII (FVIII) activity (3%), and a detectable FVIII inhibitor (1.4 Bethesda units/mL). Treatment with recombinant porcine FVIII and oral corticosteroids led to rapid control of bleeding, progressive inhibitor eradication, and complete remission, that has been maintained for 3 years. This case broadens the spectrum of autoimmune conditions associated with AHA and represents, to our knowledge, the first reported instance of AHA occurring in association with type 2 AIP. Acquired hemophilia A Autoimmune pancreatitis Susoctocog alfa Dewey 616 56 Département de médecine 221 false 11 Plaquettes et antithrombotiques 13 1407 Fibrinogène et structure du caillot 1045 335 Pancréatite aiguë 601 Hämostaseologie dbccd600-acbd-4d7c-b072-a43ffa7230e2 Article (Published version) Public case_report.pdf 251513 application/pdf fc5711687e6189c73ff16c8a92ef0e2d55f335ebc68cbc26bfe2c88979573ca4 openAccess Faculté de médecine / Section de médecine clinique / Département de médecine

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An Unusual Association Between Acquired Hemophilia A and Type 2 Autoimmune Pancreatitis	Hämostaseologie			2026	8	49

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