Higher nicotinic receptor availability in the cingulo-insular network is associated with lower cardiac parasympathetic tone

Article Article scientifique Article Higher nicotinic receptor availability in the cingulo-insular network is associated with lower cardiac parasympathetic tone eng 2019 author Garibotto Valentina 0000-0003-2422-698X 704817 author Corpataux Thibault 780039 author Dupuis Lozeron Elise 506035 author Haller Sven 711086 author Fontolliet Timothée Matthieu 635611 author Picard Fabienne 123049 1-9 10.1002/cne.24726 31168797 0021-9967 The dorsal anterior cingulate cortex (dACC) and the anterior insula (AI) constitute the salience network and form as well the major cortical components of the central autonomic nervous system. These two cortical regions have the highest density in α4β2 nicotinic acetylcholine receptors (nAChRs) within the whole cortex.The aim of the study was to test the association between nAChRs density/availability in the salience network and the heart rate variability in humans. We selected subjects from a previous positron emission tomography (PET) imaging study in epilepsy with 18F-FA-85380, a specific marker for α4β2 nAChRs, including 10 healthy controls, 10 patients with nonlesional focal epilepsy and 8 patients with idiopathic generalized epilepsy. Participants underwent a 10 min-resting electrocardiogram as they were lying still in a semi-supine position while watching an emotionally neutral video. We tested the association between parasympathetic tone and the regional brain nAChR availability, as measured by 18F-F-A-85380 binding potential (BP), using linear regression. We observed an association between higher nAChRs availability in the bilateral dACC and the right dorsal AI/frontal operculum and a lower parasympathetic tone, without significant effect of the clinical group on this relation. Our study is the first one to show a neurochemical correlate to the parasympathetic role of the anterior cingulate cortex and the AI. The nicotinic system, which plays a major role in the peripheral autonomic nervous system intervening both in the parasympathetic and sympathetic chains, seems also to play a role in the central autonomic nervous system. PET RRID:SCR_001622 RRID:SCR_001905 RRID:SCR_002823 RRID:SCR_007037 Anterior cingulate cortex Heart rate variability Insula Nicotinic receptors Dewey 616.0757 Dewey 616.8 Dewey 617 Swiss National Science Foundation PET and EEG study of the nicotinic system in epilepsy 320030_127608 CH Project funding Autre HUG PRD n°10-II-3 53 Département de neurosciences fondamentales 21A 61 Département des neurosciences cliniques 226 62 Département de radiologie et informatique médicale 227 63 Département d'anesthésiologie, pharmacologie, soins intensifs et urgences 229 false 88 Epidémiologie clinique et biostatistique 115 926 Imagerie per-opératoire multi-modalité en radiologie interventionnelle 949 1222 Laboratoire de neuroimagerie et de traceurs moléculaires innovants 984 Journal of Comparative Neurology 91403bd1-8124-481e-8ceb-d03100f347c2 Article (Published version) Restricted Garibotto_et_al-2019-Journal_of_Comparative_Neurology.pdf 3470703 application/pdf restrictedAccess Faculté de médecine / Section de médecine fondamentale / Département de neurosciences fondamentales Faculté de médecine / Section de médecine clinique / Département des neurosciences cliniques Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale Faculté de médecine / Section de médecine clinique / Département d'anesthésiologie, pharmacologie, soins intensifs et urgences

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Higher nicotinic receptor availability in the cingulo-insular network is associated with lower cardiac parasympathetic tone	Journal of Comparative Neurology	2019	369	0
Le syndrome d'Asperger dans le film Mary and Max	Swiss Archives of Neurology, Psychiatry and Psychotherapy	2016	425	228

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Corpataux, Thibault