Dynamics of affect modulation in neurodevelopmental disorders (DynAMoND) – study design of a prospective cohort study

Article Article scientifique Article Dynamics of affect modulation in neurodevelopmental disorders (DynAMoND) – study design of a prospective cohort study eng 2024-12-28 author Bayas Maximilian 0009-0001-6853-4151 Department for Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt-Goethe University, Frankfurt am Main, Germany. bayas@med.uni-frankfurt.de. author Kockler Tobias D Department for Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt-Goethe University, Frankfurt am Main, Germany.,Mental mHealth Lab, Karlsruhe Institute of Technology, Karlsruhe, Germany. author Ramos-Quiroga Josep Antoni Department for Psychiatry, Hospital Universitari Vall d'Hebron, Barcelona, Catalonia, Spain.,Group of Psychiatry, Mental Health and Addictions, Vall d'Hebron Research Institute (VHIR), Barcelona, Catalonia, Spain.,Biomedical Network Research Centre on Mental Health (CIBERSAM), Barcelona, Catalonia, Spain. author Caller Silvia Muñoz Department for Psychiatry, Hospital Universitari Vall d'Hebron, Barcelona, Catalonia, Spain.,Group of Psychiatry, Mental Health and Addictions, Vall d'Hebron Research Institute (VHIR), Barcelona, Catalonia, Spain.,Biomedical Network Research Centre on Mental Health (CIBERSAM), Barcelona, Catalonia, Spain. author Fadeuilhe Christian Department for Psychiatry, Hospital Universitari Vall d'Hebron, Barcelona, Catalonia, Spain.,Group of Psychiatry, Mental Health and Addictions, Vall d'Hebron Research Institute (VHIR), Barcelona, Catalonia, Spain.,Biomedical Network Research Centre on Mental Health (CIBERSAM), Barcelona, Catalonia, Spain. author de Girolamo Giovanni Epidemiological and Evaluation Psychiatry Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy. author Iozzino Laura Epidemiological and Evaluation Psychiatry Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy. author D'Addazio Miriam Epidemiological and Evaluation Psychiatry Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy. author Haavik Jan K.G. Jebsen Centre for Neuropsychiatric Disorders, Department of Biomedicine, University of Bergen, Bergen, Norway.,Division of Psychiatry, Haukeland University Hospital, Bergen, Norway. author Halmøy Anne Division of Psychiatry, Haukeland University Hospital, Bergen, Norway.,Department of Clinical Medicine, University of Bergen, Bergen, Norway. author Hellum Karin Schiøler Division of Psychiatry, Haukeland University Hospital, Bergen, Norway. author Kolle Joakim Njaastad Division of Psychiatry, Haukeland University Hospital, Bergen, Norway. author Osnes Berge Department of Clinical Psychology, University of Bergen, Bergen, Norway. author Lundervold Astri J Department of Biological and Medical Psychology, University of Bergen, Bergen, Norway. author Perroud Nader Ali 0000-0002-9282-9216 Department of Psychiatry, Faculty of Medicine, University of Geneva, Geneva, Switzerland.,TRE Unit, Division of Psychiatric Specialties, Department of Psychiatry, University Hospital of Geneva, Geneva, Switzerland. 94458 Département de psychiatrie (PSYAT) author Hasler Roland Department of Psychiatry, Faculty of Medicine, University of Geneva, Geneva, Switzerland.,TRE Unit, Division of Psychiatric Specialties, Department of Psychiatry, University Hospital of Geneva, Geneva, Switzerland. 510492 author Teixeira De Almeida Mélanie Department of Psychiatry, Faculty of Medicine, University of Geneva, Geneva, Switzerland.,TRE Unit, Division of Psychiatric Specialties, Department of Psychiatry, University Hospital of Geneva, Geneva, Switzerland. 779717 Département de psychiatrie (PSYAT) author Ebner-Priemer Ulrich W Mental mHealth Lab, Karlsruhe Institute of Technology, Karlsruhe, Germany. author Thanarajah Sharmili Edwin Department for Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt-Goethe University, Frankfurt am Main, Germany. author Schiweck Carmen Department for Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt-Goethe University, Frankfurt am Main, Germany. author Matura Silke Department for Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt-Goethe University, Frankfurt am Main, Germany. author Repple Jonathan Department for Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt-Goethe University, Frankfurt am Main, Germany.,Institute for Translational Psychiatry, Epidemiological and Evaluation Psychiatry, University of Münster, Münster, Germany. author Reif Andreas Department for Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt-Goethe University, Frankfurt am Main, Germany. author Aichholzer Mareike Department for Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt-Goethe University, Frankfurt am Main, Germany. 44 10.1186/s40345-024-00367-2 39733204 2194-7511 PMC11682027 https://journalbipolardisorders.springeropen.com/articles/10.1186/s40345-024-00367-2 Background: Attention-deficit/hyperactivity disorder (ADHD) is a common neuro-developmental disorder that often persists into adulthood. Moreover, it is frequently accompanied by bipolar disorder (BD) as well as borderline personality disorder (BPD). It is unclear whether these disorders share underlying pathomechanisms, given that all three are characterized by alterations in affective states, either long or short-term. BD is characterized by infrequent but intense mood shifts, while ADHD and BPD involve more dynamic emotional fluctuations. It is yet to be determined whether these disorders represent distinct phenomena or different points on a spectrum of affective dysregulation. Methods: This study seeks to distinguish the emotional dysregulation of BPD, ADHD, and BD by using digital phenotyping, a measurement burst electronic-diary method with different sampling rates, and accelerometry to measure participants' activity. Our study will include 480 participants aged 14 to 50 (120 each from BPD, ADHD, BD, and healthy control groups) from five European sites. Participants' smartphones will provide continuous data on their digital phenotypes, i.e., by indicators of physical activity and communication, for one year, along with daily evening ratings of mood and sleep. Moreover, five intensive measurement periods of five days each, called measurement bursts, will occur throughout the year, with electronic diaries asking participants to report on mood, self-esteem, impulsivity, life events, social interactions, and dysfunctional behaviors ten times a day. Moreover, participants will wear activity sensors during the five measurement bursts. Statistical analysis aims to identify whether affective dysregulation aspects share or differ across disorders. Specifically, data analysis aims to investigate the differences in parameters of affect fluctuation such as attractor strength and variability between disorders and to test the association of genetic risk factors for psychiatric disorders and resilience factors with critical parameters of affect modulation. Discussion: The results of this study offer the potential to link patients' external exposures with their affective state, reduce misdiagnosis, and determine the best timing for therapeutic interventions. Potential limitations of the study include insufficient recruitment of patients and drop-outs due to various protocol violations. Trial registration: Study code: DRKS00028917, registered 27.07.2022, https://drks.de/search/de/trial/DRKS00028917 . Affective state Ambulatory assessment Attention-deficit/hyperactivity disorder Bipolar disorder Borderline personality disorder Digital phenotyping Emotion dysregulation Dewey 616.89 European Commission Network of European funding for neuroscience research - NEURON Cofund2 964215 NEURON Cofund2 EU H2020 60 Département de psychiatrie 225 false 1342 Régulation des émotions : TDAH et trouble de la personnalité borderline 1028 International journal of bipolar disorders 12 1 7a663f6d-ed80-4dae-bcad-d9b0bdba7505 Article (Published version) Public Article_scientifique_from_unpaywall.pdf 1450689 application/pdf CC BY-4.0 8226d68f5a69148b09129f26106501bc0336ae5f2c2feebe39fd1f00108c8f9c openAccess Faculté de médecine / Section de médecine clinique / Département de psychiatrie

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