Role of protein lysine methylation in Toxoplasma gondii motility, invasion and egress

Diplôme Master Role of protein lysine methylation in Toxoplasma gondii motility, invasion and egress eng 2016 author Mangano Franck 775247 director Soldati-Favre Dominique 0000-0003-4156-2109 135114 Toxoplasma gondii is an obligate intracellular parasite belonging to the phylum Apicomplexa that can infect humans. This parasite developed a specific mechanism of invasion based on an apical complex and a mechanism of secretion. It has been observed that an apicomplexan specific methyltransferase (AKMT, Apical Lysine (K) Methyltransferase) was necessary for the mechanism of invasion, egress and motility of the parasite. More precisely, the methyltransferase activity of AKMT is essential to the apical localization of GAC (Glideosome Associated Connector). This latter connects the actomyosin system (called glideosome) with the micronemal adhesins. The moving junction (MJ) starts at the conoid and moves to the apical end of the inner membrane complex (IMC) due to the activity of the myosin H. after, the myosin A takes over from the apical end of the IMC to the basal end of the parasite. GAC is necessary for the mechanism of invasion, egress and motility, but was not demonstrated to be methylated. This study tries to identify the substrate(s) of AKMT responsible for the apical localization of GAC. Toxoplasma gondii AKMT Apical lysine methyltransferase GAC Glideosome Associated Connector Dewey 570 Dewey 616 30 Section de biologie 16 54 Département de microbiologie et médecine moléculaire 21B false 766 Groupe Soldati d56bce73-2241-4833-b80c-fb56bc915b6c Master thesis Restricted AKMTsubstrate.pdf 3794526 application/pdf restrictedAccess Faculté des sciences / Section de biologie Faculté de médecine / Section de médecine fondamentale / Département de microbiologie et médecine moléculaire

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Role of protein lysine methylation in Toxoplasma gondii motility, invasion and egress				2016	306	5

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Mangano, Franck