Oral Malignant Melanoma Initially Misdiagnosed as a Racial Pigmentation: A Case Report

Article Article scientifique Article Oral Malignant Melanoma Initially Misdiagnosed as a Racial Pigmentation: A Case Report eng 2016 author Martinelli Klay Carla Patricia 646960 author Laporte Marcel 774949 author Martinelli Celso Ricardo author Martinelli Celso author Lombardi Tommaso 22312 1-7 10.1159/000444049 27195264 2296-3529 Oral malignant melanoma (OMM) is rare, representing less than 0.5% of all oral malignancies. The most affected sites are the palate and the maxillary gingiva. Histological examination is important to establish the diagnosis of any suspicious pigmented lesion in the oral cavity, mainly if a precise clinical diagnosis is not possible. We present one case of OMM that was initially diagnosed as a racial pigmentation elsewhere 2 years earlier. Clinical examination showed multiple macules and nodules located on the hard and soft palate, gingiva and superior alveolar mucosa. These lesions were painless and presented a color variation going from dark blue to black. Histological analysis showed sheets and nests of atypical melanocytes displaying a range of shapes such as plasmacytoid, epithelioid, and round cells, located in the superficial corium extending to the deep tissues. A few tumor cells contained variable amounts of melanin. There was no invasion of blood vessels or nerve fibers. Immunohistochemical analysis revealed that the neoplastic cells were positive for HMB-45, melan-A, S-100 and negative for AE1/AE3, confirming the diagnosis of melanoma. The Ki-67 labeling index was around 25%. The patient refused any treatment and died 11 months later. Dewey 617 57 Département de chirurgie 222 false 238 Groupe Lombardi Tommaso (médecine dentaire) 313 Dermatopathology 3 1 eb9d2597-e157-4e3e-8c45-bd90a00bd367 Article (Published version) Public dpa-0003-0001.pdf 800604 application/pdf openAccess Faculté de médecine / Section de médecine clinique / Département de chirurgie

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Oral Malignant Melanoma Initially Misdiagnosed as a Racial Pigmentation: A Case Report	Dermatopathology			2016	546	215

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Laporte, Marcel