FOLFOXIRI-resistance induction in colorectal carcinoma models

Diplôme Master FOLFOXIRI-resistance induction in colorectal carcinoma models eng 2021-01-08 author Boss Sahar 774436 director Nowak-Sliwinska Patrycja 848409 Summarizing, the results generated by this study demonstrated the generation of pretreated cell lines namely HCT116, LS174T, DLD1, and SW620. By ODC chronic treatment consisting of FA, 5-FU, SN38, and OX at low doses. In 2D and 3Dcc models, all ODC lines-Pretreated were less affected by ODC treatment than ODC-naive lines. Whereas in the 3D model, only ODC-pretreated LS174T and SW620 were less affected by ODC treatment than ODC-naive cells. Finally, in 3D culture, the optimized drug combination composed of regorafenib, vemurafenib, vatalanib, and AZD4547 at low doses, showed considerable efficacy only in metastatic origin DLD1 cells, and an irrelevant effect on the HCT116 cells. Dewey 615 Master en Pharmacie 31 Section des sciences pharmaceutiques 17 false 1325 Pharmacologie moléculaire 01b43a21-724c-435e-9349-95bc1a9e0e05 Master thesis Restricted 201224151343___TPR.pdf 19960884 application/pdf restrictedAccess Faculté des sciences / Section des sciences pharmaceutiques

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FOLFOXIRI-resistance induction in colorectal carcinoma models				2021	67	7

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Boss, Sahar