Intranasal administration of resveratrol successfully prevents lung cancer in A/J mice

Article Article scientifique Article Intranasal administration of resveratrol successfully prevents lung cancer in A/J mice eng 2018 author Monteillier Aymeric 754969 author Voisin Aymone 772303 author Furrer Pascal 42164 author Allémann Eric 0000-0002-6598-9521 26730 author Cuendet Muriel 0000-0002-1523-1907 686755 14257 10.1038/s41598-018-32423-0 30250304 2045-2322 Lung cancer is the most lethal cancer in the world. About 80% of lung cancer deaths are linked to tobacco use. As a complement to tobacco control, efficient chemoprevention strategies are needed to tackle lung cancer epidemic. Resveratrol is one of the most studied natural products, notably for its cancer chemoprevention properties. However, its low oral bioavailability has often limited the translation of in vitro activities to in vivo effects. While oral administration of resveratrol effectively inhibited colorectal carcinogenesis, it failed to protect mice from chemically-induced lung carcinogenesis. Therefore, non-invasive parenteral routes must be considered to bring resveratrol to the lungs. In the present study, intranasal administration of a concentrated formulation proved to be a valid method to expose the lungs to a sufficient amount of resveratrol. This formulation was administered three times a week for 25 weeks to A/J mice having 4-[methyl(nitroso)amino]-1-(3-pyridinyl)-1-butanone-induced lung carcinogenesis. Resveratrol-treated mice showed a 27% decrease in tumour multiplicity, with smaller tumours, resulting in 45% decrease in tumour volume/mouse. In vitro investigations highlighted apoptosis as a potential mechanism of action. This study presents an effective way to overcome resveratrol low oral bioavailability, encouraging a reevaluation of its use in future clinical trials. Dewey 615 31 Section des sciences pharmaceutiques 17 false 884 Pharmacognosie 883 Technologie pharmaceutique Scientific Reports 8 1 67b74a5e-93cc-4f0f-a0a7-dbba6e58ccbb Article (Published version) Public s41598-018-32423-0.pdf 2660844 application/pdf CC BY openAccess Faculté des sciences / Section des sciences pharmaceutiques

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Intranasal administration of resveratrol successfully prevents lung cancer in A/J mice	Scientific Reports			2018	503	308

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Voisin, Aymone