Btn2a2, a T cell immunomodulatory molecule coregulated with MHC class II genes

Article Article scientifique Article Btn2a2, a T cell immunomodulatory molecule coregulated with MHC class II genes eng 2016 author Sarter Zaiss Kerstin 757311 author Leimgruber Elisa 510528 author Gobet Florian 631681 author Agrawal Vishal 827669 author Dunand-Sauthier Isabelle 134225 author Barras Emmanuele 26222 author Mastelic-Gavillet Beatris 712326 author Kamath Arun 593776 author Fontannaz Paola 88291 author Guery Leslie 757954 author Do Valle Duraes Fernanda 733292 author Lippens Carla 765790 author Ravn Ulla 38216 author Santiago-Raber Marie-Laure 556511 author Magistrelli Giovanni author Fischer Nicolas 45088 author Siegrist Claire-Anne 26816 author Hugues Stéphanie 663452 author Reith Walter 25482 177-187 10.1084/jem.20150435 26809444 0022-1007 Evidence has recently emerged that butyrophilins, which are members of the extended B7 family of co-stimulatory molecules, have diverse functions in the immune system. We found that the human and mouse genes encoding butyrophilin-2A2 (BTN2A2) are regulated by the class II trans-activator and regulatory factor X, two transcription factors dedicated to major histocompatibility complex class II expression, suggesting a role in T cell immunity. To address this, we generated Btn2a2-deficient mice. Btn2a2(-/-) mice exhibited enhanced effector CD4(+) and CD8(+) T cell responses, impaired CD4(+) regulatory T cell induction, potentiated antitumor responses, and exacerbated experimental autoimmune encephalomyelitis. Altered immune responses were attributed to Btn2a2 deficiency in antigen-presenting cells rather than T cells or nonhematopoietic cells. These results provide the first genetic evidence that BTN2A2 is a co-inhibitory molecule that modulates T cell-mediated immunity. Dewey 616.07 137 Département de pathologie et immunologie 21F false 143 Centre de vaccinologie et d'immunologie néonatale 177 221 Groupe Reith Walter (pathologie et immunologie) 282 563 Pathologie et immunologie 906 The Journal of experimental medicine 213 2 883fedb2-8d02-45af-9c5d-fdc305465e33 Article (Published version) Restricted J Exp Med-2016-Sarter-jem.20150435.pdf 1707470 application/pdf restrictedAccess Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie

Title	Published in	Year	Views	Downloads

Btn2a2, a T cell immunomodulatory molecule coregulated with MHC class II genes	The Journal of experimental medicine	2016	787	4
Role of major histocompatibility complex class II expression by non-hematopoietic cells in autoimmune and inflammatory disorders: facts and fiction	Tissue antigens	2013	627	5

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Sarter Zaiss, Kerstin