Antibiotic susceptibility and molecular epidemiology of Panton-Valentine leukocidin-positive meticillin-resistant Staphylococcus aureus: An international survey

Article Article scientifique Article Antibiotic susceptibility and molecular epidemiology of Panton-Valentine leukocidin-positive meticillin-resistant Staphylococcus aureus: An international survey eng 2014 author Macedo-Viñas Marina author Conly John 741159 author Francois Patrice 0000-0002-0540-750X 28911 author Aschbacher Richard author Blanc Dominique S author Coombs Geoffrey author Daikos George author Dhawan Benu author Empel Joanna author Etienne Jerome author Figueiredo Agnes Marie Sá author Han Lizhong author Kim Hong Bin author Köck Robin author Larsen Anders author Layer Franziska author Lo Janice author Maeda Tadashi author Mulvey Michael Joséph 75495 author Pantosti Annalisa author Saga Tomoo author Schrenzel Jacques 29184 author Simor Andrew author Skov Robert author Van Rijen Miranda author Wang Hui 630388 author Zakaria Zunita 43-47 10.1016/j.jgar.2013.08.003 27873637 2213-7165 http://ac.els-cdn.com/S221371651300088X/1-s2.0-S221371651300088X-main.pdf?_tid=0192bf2c-9246-11e7-b512-00000aacb35f&acdnat=1504621683_fa7e755fc2a9476c3874dcdfa97d33e0 The antibiotic susceptibility and molecular epidemiology of Panton-Valentine leukocidin (PVL)-positive meticillin-resistant Staphylococcus aureus (MRSA) isolates reported from 17 countries in the Americas, Europe and, Australia-Asia were analysed. Among a total of 3236 non-duplicate isolates, the lowest susceptibility was observed to erythromycin in all regions. Susceptibility to ciprofloxacin showed large variation (25%, 75% and 84% in the Americas, Europe and Australia-Asia, respectively). Two vancomycin-intermediate PVL-positive MRSA isolates were reported, one from Hong Kong and the other from The Netherlands. Resistance to trimethoprim/sulfamethoxazole and linezolid was <1%. Among 1798 MRSA isolates from 13 countries that were tested for the requested 10 non-β-lactam antibiotics, 49.4% were multisusceptible. However, multiresistant isolates (resistant to at least three classes of non-β-lactam antibiotics) were reported from all regions. Sequence type 30 (ST30) was reported worldwide, whereas ST80 and ST93 were exclusive to Europe and Australia, respectively. USA300 and related clones (ST8) are progressively replacing the ST80 clone in several European countries. Eight major clusters were discriminated by multilocus variable-number tandem repeat assay (MLVA), showing a certain geographic specificity. PVL-positive MRSA isolates frequently remain multisusceptible to non-β-lactam agents, but multiresistance is already prevalent in all regions. Surveillance of MRSA susceptibility patterns should be monitored to provide clinicians with the most current information regarding changes in resistance patterns. Dewey 616 56 Département de médecine 221 false 338 Génomique et microbiote 604 Journal of Global Antimicrobial Resistance 2 1 2dc726e5-b33d-4a87-ab28-6638bbecd08d Article (Published version) Restricted 1-s2.0-S221371651300088X-main.pdf 578726 application/pdf restrictedAccess Faculté de médecine / Section de médecine clinique / Département de médecine

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Antibiotic susceptibility and molecular epidemiology of Panton-Valentine leukocidin-positive meticillin-resistant Staphylococcus aureus: An international survey	Journal of Global Antimicrobial Resistance			2014	590	0

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Mulvey, Michael Joséph