Odor representations in the olfactory bulb evolve after the first breath and persist as an odor afterimage

Article Article scientifique Article Odor representations in the olfactory bulb evolve after the first breath and persist as an odor afterimage eng 2013 author Patterson Michaël 754791 author Lagier Samuel 755541 author Carleton Alan 676577 E3340-E3349 10.1073/pnas.1303873110 23918364 0027-8424 Rodents can discriminate odors in one breath, and mammalian olfaction research has thus focused on the first breath. However, sensory representations dynamically change during and after stimuli. To investigate these dynamics, we recorded spike trains from the olfactory bulb of awake, head-fixed mice and found that some mitral cells' odor representations changed following the first breath and others continued after odor cessation. Population analysis revealed that these postodor responses contained odor- and concentration-specific information—an odor afterimage. Using calcium imaging, we found that most olfactory glomerular activity was restricted to the odor presentation, implying that the afterimage is not primarily peripheral. The odor afterimage was not dependent on odorant physicochemical properties. To artificially induce aftereffects, we photostimulated mitral cells using channelrhodopsin and recorded centrally maintained persistent activity. The strength and persistence of the afterimage was dependent on the duration of both artificial and natural stimulation. In summary, we show that the odor representation evolves after the first breath and that there is a centrally maintained odor afterimage, similar to other sensory systems. These dynamics may help identify novel odorants in complex environments. Multielectrode recording Network dynamics Optogenetics Mouse olfaction Dewey 616.8 European Commission From neurons to behavior: analysis of the mechanisms underlying sensory coding and plasticity in chemical senses 243344 NEUROCHEMS EU FP7 Swiss National Science Foundation Maturation of adult-born interneurons and consequences on sensory perception 119169 CH Careers Swiss National Science Foundation mechanisms underlying sensory coding and plasticity in olfaction 139189 CH Careers 16 Centre interfacultaire de neurosciences 0D9 53 Département de neurosciences fondamentales 21A false 536 Groupe Carleton Alan (neurosciences fondamentales) 876 Proceedings of the National Academy of Sciences of the United States of America 110 35 48ed2f41-051e-4fca-a725-62a66e3c42a9 Article (Published version) Restricted pattersonPNAS2013.pdf 2542543 application/pdf restrictedAccess Centres et instituts / Centre interfacultaire de neurosciences Faculté de médecine / Section de médecine fondamentale / Département de neurosciences fondamentales

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Odor representations in the olfactory bulb evolve after the first breath and persist as an odor afterimage	Proceedings of the National Academy of Sciences of the United States of America			2013	697	2

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Patterson, Michaël