Early alterations of large-scale brain networks temporal dynamics in young children with autism

Article Article scientifique Article Early alterations of large-scale brain networks temporal dynamics in young children with autism eng 2021-08-16 2021-08-16 author Bochet Aurélie 0000-0002-5476-6170 Department of Psychiatry, University of Geneva, Geneva, Switzerland. aurelie.bochet@unige.ch. 754197 author Sperdin Holger Franz 0000-0002-3438-1572 Department of Psychiatry, University of Geneva, Geneva, Switzerland. holger.sperdin@unige.ch. 511736 author Rihs Tonia Functional Brain Mapping Laboratory, Department of Fundamental Neurosciences, University of Geneva, Geneva, Switzerland. 628961 author Kojovic Nada 0000-0003-0116-2485 Department of Psychiatry, University of Geneva, Geneva, Switzerland. 776933 Département de psychiatrie (PSYAT) author Franchini Martina Department of Psychiatry, University of Geneva, Geneva, Switzerland. 692500 Section de psychologie (PSICO) author Jan Reem Kais College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates. author Michel Christoph 0000-0003-3426-5739 Functional Brain Mapping Laboratory, Department of Fundamental Neurosciences, University of Geneva, Geneva, Switzerland. 91629 Département de neurosciences fondamentales (NEUFO) author Schaer Marie 0000-0001-8479-6365 Department of Psychiatry, University of Geneva, Geneva, Switzerland. 510515 Département de psychiatrie (PSYAT) 968 10.1038/s42003-021-02494-3 34400754 2399-3642 PMC8367954 Autism spectrum disorders (ASD) are associated with disruption of large-scale brain network. Recently, we found that directed functional connectivity alterations of social brain networks are a core component of atypical brain development at early developmental stages in ASD. Here, we investigated the spatio-temporal dynamics of whole-brain neuronal networks at a subsecond scale in 113 toddlers and preschoolers (66 with ASD) using an EEG microstate approach. We first determined the predominant microstates using established clustering methods. We identified five predominant microstate (labeled as microstate classes A-E) with significant differences in the temporal dynamics of microstate class B between the groups in terms of increased appearance and prolonged duration. Using Markov chains, we found differences in the dynamic syntax between several maps in toddlers and preschoolers with ASD compared to their TD peers. Finally, exploratory analysis of brain-behavioral relationships within the ASD group suggested that the temporal dynamics of some maps were related to conditions comorbid to ASD during early developmental stages. Autism Spectrum Disorder / physiopathology Brain / physiopathology Brain Mapping Child, Preschool Female Humans Infant Male Neural Pathways / physiopathology Dewey 616.89 Dewey 616.8 Swiss National Science Foundation NCCR 'SYNAPSY - The synaptic bases of mental diseases' (phase III) 185897 CH Programmes Swiss National Science Foundation Measuring trajectories of cerebral development associated with autism in the first years of life 163859 CH Careers Swiss National Science Foundation Measuring trajectories of cerebral development associated with autism in the first years of life 190084 CH Careers Swiss National Science Foundation Understanding the comorbidity between Autism Spectrum Disorders and Attention Deficit/Hyperactivity Disorder 183979 CH Careers 60 Département de psychiatrie 225 53 Département de neurosciences fondamentales 21A false 118 Organisation et plasticité des réseaux neuronaux cérébraux 148 1360 Autism Brain and Behavior Lab 1033 1284 NCCR Synapsy Communications biology 4 1 0419eb66-edcb-4ea3-80ff-46e612778680 Article (Published version) Public Article-scientifique-from-europePmc.pdf 2027391 application/pdf CC BY-4.0 9249dce6467c9a4b27f971d35f91357165c06fc6fdf6868a251d156821ab4244 151692b8-ee3f-48af-a69e-236d9658056f Appendix Public 42003_2021_2494_MOESM4_ESM.pdf 387817 application/pdf e9164302774c43ba137e77105058f6192351e15f472a4b2716e73b4a7bb29eb8 a96183d0-2629-4182-8b08-048db7bd6603 Appendix Public 42003_2021_2494_Fig6_HTML.jpg 69390 image/jpeg 0255bd84c002653a4ac81a64ad82fb63cbc10e216c778389fdfe9f50a9cd42bf 41b7aa80-2241-4d5e-a116-dcdeb10e580a Appendix Public 42003_2021_2494_Fig1_HTML.jpg 90292 image/jpeg 92d4e4535cb271a6285cb932639270aaea03c2d50513b8dd7943a385ece19e41 dbc86cad-6ad4-417e-90f3-367c8b4aefbe Appendix Public 42003_2021_2494_Fig3_HTML.jpg 86668 image/jpeg 59f73dd4248564b46d09f5b6d3457397482e9046a997ac1aadcb76a84292322c 7d2cbd56-7c1a-4054-b214-dbb0c8c18496 Appendix Public 42003_2021_2494_MOESM2_ESM.pdf 1739814 application/pdf 0a93d5c0aba602529602ba78c2886ff3bd7c38cf7290c633d169422de2296bbf d18f6fbf-7215-42b6-8a0f-144dc6902c1b Appendix Public 42003_2021_2494_MOESM3_ESM.pdf 360806 application/pdf 4c4930311f9e6fe0f9411d8aecf46fda07a8ce71330c149faad9a34e6879415d b4e3bde9-5d44-446e-8225-130ac6da0df8 Appendix Public 42003_2021_2494_Fig7_HTML.jpg 311450 image/jpeg ef84c31c5d1429b4168e4ee0b1e0ae058fb52b173d90812ea20c5a7535e329fe 2c5575cb-7e10-44d8-84df-6e4bc3164c9f Appendix Public 42003_2021_2494_Fig4_HTML.jpg 75270 image/jpeg db9eca67c5a2f042b9ba728c829daa9109978f6a25a9ab0632a84105842948b8 e7607b5f-55de-4a89-a85c-24766f6b2571 Appendix Public 42003_2021_2494_Fig2_HTML.jpg 88184 image/jpeg 85b7b92f5d527195227aa301bb872c301fb6ef9ee7befe881d7776c895b002f7 bc59cf46-a99c-43a5-8295-2780a5c0c305 Appendix Public 42003_2021_2494_Fig5_HTML.jpg 107543 image/jpeg f9a500ad9b0081bf73ba30699b181ed10527f7b922bb810ef7a437517d3e351d acfddcd0-ee94-4101-850b-1f626e9e06bf Appendix Public 42003_2021_2494_MOESM1_ESM.xlsx 30601 application/vnd.openxmlformats-officedocument.spreadsheetml.sheet 380905fe95a9878ae65f2f758b65747d2582a2ef2afe38b366be0d5af9f0a500 openAccess Faculté de médecine / Section de médecine clinique / Département de psychiatrie Faculté de médecine / Section de médecine fondamentale / Département de neurosciences fondamentales

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