Hypofractionated radiotherapy for prostate cancer in the postoperative setting: What is the evidence so far?

Article Article scientifique Article Hypofractionated radiotherapy for prostate cancer in the postoperative setting: What is the evidence so far? eng 2018 author Picardi Cristina 861165 author Perret Ioan Alexandre 750807 author Miralbell Raymond 116361 author Zilli Thomas 791833 91-96 10.1016/j.ctrv.2017.11.004 29178983 0305-7372 Postoperative external beam radiation therapy (EBRT) is a validated treatment option in the adjuvant setting for prostate cancer patients with aggressive pathological features following radical prostatectomy (RP) or as salvage modality in patients with biochemical recurrence after RP. Contemporary randomized phase III trials have provided evidence for using hypofractionation in the definitive treatment setting as an alternative to standard fractionated regimens. Biomathematical modeling for prostate cancer fractionated EBRT associated with widely available refined treatment delivery techniques such as volumetric modulated-arc therapy with image-guided RT may improve the therapeutic ratio. Nevertheless, the role of hypofractionation in the postoperative setting still remains investigational. In this systematic review of the literature we reviewed the role of hypofractionation for postoperative EBRT in the adjuvant or salvage setting in prostate cancer patients previously treated by RP. A favorable acute toxicity profile with, at least, as good biochemical control rates with hypofractionation has been suggested. And yet conflicting results have been reported concerning long-term genitourinary late toxicity. Prospective studies are eagerly awaited to assess the role of hypofractionation in the postoperative setting. Dose Hypofractionation Humans Male Prostatectomy Prostatic Neoplasms/radiotherapy Radiotherapy, Adjuvant/methods Radiotherapy, Image-Guided Radiotherapy, Intensity-Modulated Salvage Therapy Dewey 616.0757 62 Département de radiologie et informatique médicale 227 false 413 Groupe Miralbell Raymond (radio-oncologie) 685 Cancer Treatment Reviews 62 8446a897-be44-4d03-886a-5798d2c3658b Article (Published version) Restricted PMID29178983.pdf 303473 application/pdf restrictedAccess Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale

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Hypofractionated radiotherapy for prostate cancer in the postoperative setting: What is the evidence so far?	Cancer Treatment Reviews			2018	471	0

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Perret, Ioan Alexandre