Drug-conjugate micelle systems for the targeted topical administration of anti-acne drugs to the skin

Diplôme Thèse Drug-conjugate micelle systems for the targeted topical administration of anti-acne drugs to the skin eng 2025-07-10 2025-07-17 author Pinto Laeticia 749466 director Kalia Yogeshvar 0000-0001-9049-5489 503798 Section des sciences pharmaceutiques (FARMA) 10.13097/archive-ouverte/unige:187951 urn:nbn:ch:unige-1879518 Sc. Vie - Pharma. 358 The aim of this PhD work was to improve the skin bioavailability of two compounds used in the treatment of acne by targeting the primary site of the disease: the pilosebaceous unit (PSU). The main idea was to synthesize a conjugate composed of an active compound and an amphiphilic polymer capable of self-assembling into micelles in aqueous media. Micelles offer several advantages, such as increasing the skin bioavailability of active compounds, and more importantly in our case, it has been shown that they can target skin appendages like the PSU. <b>The specific objective of this work was to synthesize these conjugates and characterize them in terms of size, shape, stability, and micelle-forming capacity. Once these properties were established, the next step was to evaluate the micelles in contact with the skin and determine their ability to deliver the active ingredient. Another potential benefit of these conjugates is that they could also serve as carriers for other active ingredients, which is particularly relevant in the treatment of acne, where combination therapies are often used.</b> Acne Polymeric micelles Dewey 615 31 Section des sciences pharmaceutiques 17 false 74f67791-f93e-4fe4-a070-fddb7e91da16 Thesis Restricted PINTOLaeticia_these358vf_pdf.pdf 5789632 application/pdf Private 2026-09-30 7ba51f4ebc36b374ecac7c734f60438675b83f3fbd88f23c381b6b55f9f46a35 d18d2196-087d-49ff-b0d0-1f3eacc88af4 Imprimatur Public Imprimatur.pdf 3861848 application/pdf 2cc16d23b678205c38ba1402c918c00df0fc644f5d3b75407c0dc2652cb4cfad embargoedAccess Faculté des sciences / Section des sciences pharmaceutiques

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Drug-conjugate micelle systems for the targeted topical administration of anti-acne drugs to the skin				2025	126	0

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