Description of a European memory clinic cohort undergoing amyloid-PET: The AMYPAD Diagnostic and Patient Management Study

Article Article scientifique Article Description of a European memory clinic cohort undergoing amyloid-PET: The AMYPAD Diagnostic and Patient Management Study eng 2022-06-17 2023-03 author Altomare Daniele 0000-0003-1905-8993 Laboratory of Neuroimaging of Aging (LANVIE), University of Geneva, Geneva, Switzerland.,Geneva Memory Center, Geneva University Hospitals, Geneva, Switzerland. 917820 author Collij Lyduine Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers (UMC) - Location VUmc, Amsterdam, The Netherlands. author Caprioglio Camilla Laboratory of Neuroimaging of Aging (LANVIE), University of Geneva, Geneva, Switzerland.,Geneva Memory Center, Geneva University Hospitals, Geneva, Switzerland. 936006 author Scheltens Philip Alzheimer Center, Department of Neurology, Amsterdam University Medical Centers (UMC) - Location VUmc, Amsterdam, The Netherlands. author van Berckel Bart N M Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers (UMC) - Location VUmc, Amsterdam, The Netherlands. author Alves Isadora Lopes Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers (UMC) - Location VUmc, Amsterdam, The Netherlands. author Berkhof Johannes Department of Epidemiology and Data Science, Amsterdam University Medical Centers (UMC) - Location VUmc, Amsterdam, The Netherlands. author de Gier Yvonne Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers (UMC) - Location VUmc, Amsterdam, The Netherlands. author Garibotto Valentina 0000-0003-2422-698X Laboratory of Neuroimaging and Innovative Molecular Tracers (NIMTlab), Geneva University Neurocenter and Faculty of Medicine, University of Geneva, Geneva, Switzerland.,Division of Nuclear Medicine and Molecular Imaging, Geneva University Hospitals, Geneva, Switzerland. 704817 Département de radiologie et informatique médicale (RADIO) author Moro Christian Laboratory of Neuroimaging of Aging (LANVIE), University of Geneva, Geneva, Switzerland.,Geneva Memory Center, Geneva University Hospitals, Geneva, Switzerland. 507083 author Poitrine Léa Laboratory of Neuroimaging of Aging (LANVIE), University of Geneva, Geneva, Switzerland.,Geneva Memory Center, Geneva University Hospitals, Geneva, Switzerland. 746202 author Delrieu Julien Gérontopôle, Department of Geriatrics, Toulouse University Hospital, Toulouse, France.,Maintain Aging Research team, CERPOP, Inserm, Université Paul Sabatier, Toulouse, France. author Payoux Pierre Department of Nuclear Medicine, Toulouse University Hospital, Toulouse, France.,Toulouse NeuroImaging Center (ToNIC), Inserm, Université Paul Sabatier, Toulouse, France. author Saint-Aubert Laure Department of Nuclear Medicine, Toulouse University Hospital, Toulouse, France.,Toulouse NeuroImaging Center (ToNIC), Université de Toulouse, Inserm, Université Paul Sabatier, Toulouse, France. author Molinuevo José Luis Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.,H. Lundbeck A/S, Copenhagen, Denmark. author Grau-Rivera Oriol Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.,Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.,Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES), Madrid, Spain. author Gispert Juan-Domingo Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.,Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.,Centro de Investigación Biomédica en Red Bioingeniería, Biomateriales y Nanomedicina, (CIBER-BBN), Barcelona, Spain. author Minguillón Carolina Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.,Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.,Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES), Madrid, Spain. author Fauria Karine Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.,Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES), Madrid, Spain. author Sanchez Marta Felez Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain. author Rădoi Andreea Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain. author Drzezga Alexander Department of Nuclear Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Germany.,German Center for Neurodegenerative Diseases (DZNE), Bonn-Cologne, Germany.,Institute of Neuroscience and Medicine (INM-2), Molecular Organization of the Brain, Forschungszentrum Jülich, Germany. author Jessen Frank Department of Psychiatry, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. author Escher Claus Department of Psychiatry, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. author Zeyen Philip Department of Psychiatry, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. author Nordberg Agneta Department of Neurobiology, Care Sciences and Society, Center of Alzheimer Research, Karolinska Institutet, Stockholm, Sweden.,Theme Aging, Karolinska University Hospital, Stockholm, Sweden. author Savitcheva Irina Medical Radiation Physics and Nuclear Medicine, Section for Nuclear Medicine, Karolinska University Hospital, Stockholm, Sweden. author Jelic Vesna Cognitive Disorders Clinic, Theme Inflammation and Aging, Karolinska University Hospital-Huddinge, Stockholm, Sweden. author Walker Zuzana Division of Psychiatry, University College London, London, UK.,St. Margaret's Hospital, Essex Partnership University NHS Foundation Trust, Essex, UK. author Lee Ho-Yun St. Margaret's Hospital, Essex Partnership University NHS Foundation Trust, Essex, UK. author Lee Lean Division of Psychiatry, University College London, London, UK. author Demonet Jean-François Leenaards Memory Center, Lausanne University Hospital (CHUV), Lausanne, Switzerland. author Plaza Wuthrich Sonia Leenaards Memory Center, Lausanne University Hospital (CHUV), Lausanne, Switzerland. author Gismondi Rossella Life Molecular Imaging, Berlin, Germany. author Farrar Gill GE Healthcare, Amersham, UK. author Barkhof Frederik Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers (UMC) - Location VUmc, Amsterdam, The Netherlands.,Institutes of Neurology and Healthcare Engineering, UCL, London, UK. author Stephens Andrew W Life Molecular Imaging, Berlin, Germany. author Frisoni Giovanni Laboratory of Neuroimaging of Aging (LANVIE), University of Geneva, Geneva, Switzerland.,Geneva Memory Center, Geneva University Hospitals, Geneva, Switzerland. 810190 dept de réadaptation et gériatrie (MIGRG) AMYPAD Consortium 844-856 10.1002/alz.12696 35715930 1552-5260 https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.12696 Introduction: AMYPAD Diagnostic and Patient Management Study (DPMS) aims to investigate the clinical utility and cost-effectiveness of amyloid-PET in Europe. Here we present participants' baseline features and discuss the representativeness of the cohort. Methods: Participants with subjective cognitive decline plus (SCD+), mild cognitive impairment (MCI), or dementia were recruited in eight European memory clinics from April 16, 2018, to October 30, 2020, and randomized into three arms: ARM1, early amyloid-PET; ARM2, late amyloid-PET; and ARM3, free-choice. Results: A total of 840 participants (244 SCD+, 341 MCI, and 255 dementia) were enrolled. Sociodemographic/clinical features did not differ significantly among recruiting memory clinics or with previously reported cohorts. The randomization assigned 35% of participants to ARM1, 32% to ARM2, and 33% to ARM3; cognitive stages were distributed equally across the arms. Discussion: The features of AMYPAD-DPMS participants are as expected for a memory clinic population. This ensures the generalizability of future study results. Alzheimer's PET Amyloid Dementia Memory clinic population Mild cognitive impairment Subjective cognitive decline Dewey 616.0757 Dewey 618.97 European Commission Amyloid imaging to Prevent Alzheimer’s Disease – Sofia ref.: 115952 115952 AMYPAD EU H2020 62 Département de radiologie et informatique médicale 227 65 Département de réadaptation et gériatrie 22B false 853 Troubles de mémoire et maladie d'Alzeimer 935 1222 Laboratoire de neuroimagerie et de traceurs moléculaires innovants 984 1132 LANVIE - Laboratoire de Neuroimagerie Alzheimer's & dementia 19 3 b5294c21-92a2-4664-8349-8a795e5272f7 Article (Published version) Public file1.pdf 1053796 application/pdf CC BY-NC-4.0 cd53b79b69a9f646dcd947948e6a3b3ab86781dd18e370d4a953f983843a94cc 8db0979e-14cd-4613-a5e7-53ba96452119 Supplemental data Public alz12696-sup-0001-suppmat.docx 92648 application/vnd.openxmlformats-officedocument.wordprocessingml.document c3af36145508d6bdc886cd642abcf193372db76985c3b6449b66ced8c9ad9d1e openAccess Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale Faculté de médecine / Section de médecine clinique / Département de réadaptation et gériatrie

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