GLI1-Altered Mesenchymal Tumours in the Head and Neck : A Case Report and Literature Review

Article Article scientifique Rapport de cas GLI1-Altered Mesenchymal Tumours in the Head and Neck : A Case Report and Literature Review eng 2025-01-31 author Janjic Olivier 736194 author De Vito Claudio 0000-0002-4966-1278 795706 author Lobrinus Johannes Alexander 647649 author Becker Minerva 0000-0001-9644-9053 134255 Département de radiologie et informatique médicale (RADIO) author Dulguerov Nicolas 0000-0001-8676-3698 503034 2 10.3390/ohbm6010002 2504-463X https://www.mdpi.com/2504-463X/6/1/2 <p>Background and Clinical Significance: GLI1 gene alterations have recently been identified as a pathological phenomenon associated with a distinct novel entity of mesenchymal neoplasms. They have been reported to occur in any soft tissue of the body, with a specific affinity for the head and neck region. The aim of this article is to increase awareness of this entity and provide a detailed summary of the modes of presentation and diagnostic and therapeutic issues surrounding these tumours occurring in the head and neck region. Case Presentation: We report the case of a 39-year-old male patient with ACTB::GLI1 fusion-related mesenchymal tongue tumour who was successfully treated by surgery. Conclusions: GLI1-altered mesenchymal tumours in the head and neck may harbour various clinical presentations. Larger series are needed to better define the clinicopathological range of this novel entity. We suggest a follow-up period of at least 2 years with imaging, followed by a clinical follow-up of 3 years. Certain clinicopathological features may warrant further and more extensive follow-up.</p> GLI1 gene Head and neck surgery Rare tumour Tongue Genetic alteration Dewey 616.8 Dewey 616.0757 Dewey 616.07 62 Département de radiologie et informatique médicale 227 61 Département des neurosciences cliniques 226 137 Département de pathologie et immunologie 21F false 411 Groupe Becker Minerva (imagerie ORL) 683 Journal of otorhinolaryngology, hearing and balance medicine 6 1 982239c2-fb97-4ea6-a0d6-b27493cfd6b2 Article (Published version) Public 2025_GLI1-Altered_Mesenchymal_Tumou.pdf 1803414 application/pdf CC BY-4.0 2558637e1d111e020f3f8f72da1e0cd9b01fcb86b1dbc115bd1d432bc452a2d0 openAccess Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale Faculté de médecine / Section de médecine clinique / Département des neurosciences cliniques Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie

Title	Published in	Year	Views	Downloads

Métastases au rectum : une revue systématique de la littérature		2025	53	98
GLI1-Altered Mesenchymal Tumours in the Head and Neck : A Case Report and Literature Review	Journal of otorhinolaryngology, hearing and balance medicine	2025	33	45

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Janjic, Olivier

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