Mimicking synaptic effects of addictive drugs with selective dopamine neuron stimulation

Article Article scientifique Article Mimicking synaptic effects of addictive drugs with selective dopamine neuron stimulation eng 2011 author Brown Matthew 696362 author Korn Clio 734977 author Luescher Christian 132337 461-463 10.4161/chan.5.6.17120 21785269 1933-6950 The synaptic changes induced by initial drug exposure leave a trace on neural systems that can eventually manifest in compulsive drug-seeking behavior. A single injection of cocaine has been shown to induce a change in the AMPA receptor (AMPAR) subunit composition at glutamatergic synapses onto ventral tegmental area (VTA) dopamine (DA) neurons. This change is long-lasting (up to months following self-administration) and represents an important functional change at the synaptic level following cocaine use. We recently published findings that cocaine's action at the DA transporter (DAT) is necessary for the induction of AMPAR redistribution and that this can also be mimicked by selective DA neuron stimulation. The stimulation effect is dependent on D1 receptors within the VTA. Furthermore other addictive drugs, although they act through distinct mechanisms, also induce this synaptic change. Here we discuss literature that expands on these observations in an attempt to further clarify the synaptic changes following early drug use. Animals Cocaine/adverse effects/pharmacokinetics/pharmacology Cocaine-Related Disorders/metabolism Dopaminergic Neurons/metabolism Humans Receptors, Dopamine D1/metabolism Receptors, Glutamate/metabolism Synapses/metabolism Dewey 616.8 53 Département de neurosciences fondamentales 21A false 271 Mécanismes cellulaires de la dépendance et de l'addiction 520 Channels 5 6 fbfaf884-545a-4088-8ef7-37e232d9eb24 Article (Published version) Restricted Channels2011MB.pdf 268686 application/pdf restrictedAccess Faculté de médecine / Section de médecine fondamentale / Département de neurosciences fondamentales

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Korn, Clio