Ethanol-induced urticaria: elevated tryptase levels after double-blind, placebo-controlled challenge

Article Article scientifique Article Ethanol-induced urticaria: elevated tryptase levels after double-blind, placebo-controlled challenge eng 1998 author Emonet Stéphane 0000-0002-1201-742X 89139 Stéphane Paul Emonet author Hogendijk Sietse Bauke 32318 author Voegeli Jérôme 29975 author Eigenmann Philippe 0000-0003-1738-1826 73268 author Roux Nicolas 37473 author Hauser Catherine Yamile 72786 181-182 10.1159/000017995 9732172 1018-8665 We present a 48-year-old patient who complained for 1 year about urticarial reactions which appeared always when he ingested alcoholic beverages. Skin prick tests with ethanol were negative but positive with 10% acetic acid in the patient. Normal controls tested negative with acetic acid. Skin prick tests to common immediate-type allergens were negative. The patient underwent a double-blind, placebo-controlled challenge test. A few minutes after challenge with ethanol but not with placebo, the patient developed erythema and wheals on the chest and the upper arms. The tryptase serum level rose from undetectable (0.1 U/ml) before challenge to 3.8 U/ml after skin lesions had appeared. This case demonstrates that increased tryptase serum levels can help in the diagnosis of ethanol-induced urticaria. Alcoholic Beverages/adverse effects Chymases Double-Blind Method Ethanol/adverse effects Humans Male Middle Aged Placebos Serine Endopeptidases/blood/drug effects Skin/drug effects/enzymology/pathology Skin Tests Tryptases Urticaria/chemically induced/enzymology Dewey 618 58 Département de pédiatrie, gynécologie et obstétrique 223 false 154 Pathogenèse et traitement des allergies alimentaires 191 Dermatology 197 2 7f81f5a5-0a5a-4f4c-a7f4-173b939c4a56 Article (Published version) Restricted 181-182.pdf 41354 application/pdf restrictedAccess Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique

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Ethanol-induced urticaria: elevated tryptase levels after double-blind, placebo-controlled challenge	Dermatology			1998	518	0

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Hauser, Catherine Yamile