Mitochondrial outer membrane permeabilization during apoptosis: the role of mitochondrial fission

Article Article scientifique Article Mitochondrial outer membrane permeabilization during apoptosis: the role of mitochondrial fission eng 2011 author Landes Thomas 726534 author Martinou Jean-Claude 27293 540-545 10.1016/j.bbamcr.2011.01.021 21277336 0006-3002 Mitochondria continually fuse and divide to yield a dynamic interconnected network throughout the cell. During apoptosis, concomitantly with permeabilization of the mitochondrial outer membrane (MOMP) and cytochrome c release, mitochondria undergo massive fission. This results in the formation of small, round organelles that tend to aggregate around the nucleus. Under some circumstances, preceding their fission, mitochondria tend to elongate and to hyperfuse, a process that is interpreted as a cell defense mechanism. Since many years, there is a controversy surrounding the physiological relevance of mitochondrial fragmentation in apoptosis. In this review, we present recent advances in this field, describe the mechanisms that underlie this process, and discuss how they could cooperate with Bax to trigger MOMP and cytochrome c release. This article is part of a Special Issue entitled Mitochondria: the deadly organelle. Animals Apoptosis Cell Membrane Permeability/physiology Humans Mitochondria/metabolism/pathology Mitochondrial Membranes/metabolism Dewey 570 46 Département de biologie cellulaire 165 false Biochimica et biophysica acta 1813 4 dd07aade-83d1-4daa-bf58-34b07161fb65 Article (Published version) Restricted landes t.pdf 486115 application/pdf restrictedAccess Faculté des sciences / Section de biologie / Département de biologie cellulaire

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Mitochondrial outer membrane permeabilization during apoptosis: the role of mitochondrial fission	Biochimica et biophysica acta			2011	645	0

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Landes, Thomas