Basic principles of host-pathogen interactions via sugars and their functional annotation for enriching SugarBindDB

Diplôme Master Basic principles of host-pathogen interactions via sugars and their functional annotation for enriching SugarBindDB eng 2013 author Tadoori Leelapavan 726496 director Lisacek Frédérique 0000-0002-0948-4537 639315 Glycobiology deals with carbohydrates or sugars and understanding their biology. The sugar structures are problematic; being linear and also branched, the inter-monomeric links are not constant. Thus highly modernized tools like MS, LC-MS, NMR etc. are required to define a given glycan structure. These sugars play many significant biological roles in an organism and in the present study the information on the role of these glycans, more importantly glycoproteins (glycans bound to proteins) or glycolipids (glycans bound to lipids) and other glycan forms involved in the host-pathogen interactions are considered, extracted and reported in the Sugarbind database. Pathogens are believed to bind the sugar moieties on the host cell membrane with their proteins called lectins or adhesins and vice versa by the host for their interactions. The Sugarbind database reports the information regarding the different pathogens and lectins, adhesins or fimbrial proteins that bind the host sugar moieties along with citation information. The information in the database is extracted and annotated from more than one hundred and seventy (170) citations or research publications so far and with more than a thousand entries being reported in the database. In the present study a test curation is performed in order to review data consistency and extract new information from the articles that can be included in the database. This work is extended while focusing on Helicobacter species. This effort resulted in strengthening control checks in the curation process and proposing new fields that complement existing ones. Glycobiology Annotation Database Glycan Host-pathogen interactions Carbohydrate or Ligand Lectin Protein Adhesin Fimbriae Gene Dewey 570 Master's degree in Biology orientation in Bioinformatics and data analysis in biology 46 Département de biologie cellulaire 165 false 405b9ec3-ed88-49e8-9c17-4f861cf66d82 Swiss Institute of Bioinformatics (SIB) e9bbf65b-3fa3-47a8-91e6-1468a41cfa8c Master thesis Restricted Master Thesis-Pavan.pdf 2888876 application/pdf restrictedAccess Faculté des sciences / Section de biologie / Département de biologie cellulaire

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Basic principles of host-pathogen interactions via sugars and their functional annotation for enriching SugarBindDB				2013	536	0

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Tadoori, Leelapavan