1-year radiological, functional and quality-of-life outcomes in patients with SARS-CoV-2 pneumonia

Article Article scientifique Revue de la littérature 1-year radiological, functional and quality-of-life outcomes in patients with SARS-CoV-2 pneumonia - A prospective observational study eng 2022-03-03 2022-03-03 author Marando Marco 0000-0003-4849-5164 author Fusi-Schmidhauser Tanja 0000-0002-6270-1035 915491 author Tamburello Adriana 0000-0002-3799-9001 author Grazioli Gauthier Lorenzo author Rigamonti Elia 0000-0002-8726-6244 author Argentieri Gianluca author Puligheddu Carla author Pagnamenta Alberto 830960 author Valenti Antonio author Pons Marco 725833 author Gianella Pietro 552050 8 10.1038/s41533-022-00273-z 35241685 2055-1010 PMC8894490 https://www.nature.com/articles/s41533-022-00273-z All over the world, SARS-CoV-2 pneumonia is causing a significant short and medium-term morbidity and mortality, with reported persisting symptoms, radiological and lung alterations up to 6 months after symptoms onset. Nevertheless, the 1-year impact on affected patients is still poorly known. In this prospective observational study, 39 patients with SARS-CoV-2 pneumonia were recruited from a single COVID-19 hospital in Southern Switzerland. They underwent a 3-month and 1-year follow-ups. At 1 year, 38 patients underwent functional follow-up through lung function tests and six minutes walking test and submitted SF-12 and SGRQ questionnaires about health-related quality of life. At 1 year most of the patients showed a persistence of the radiological and functional abnormalities and a reduction of the health-related quality of life. Thirty patients (96.8%) still presented some residual abnormalities on CT scans (31 patients at 3 months), though with a general reduction of the lesional load in all lung lobes. Twenty patients (52.6%) had persisting lung function tests impairment, with an overall improvement of DLCO. As concerning the functional status, lowest SpO2 during 6MWT increased significantly. Finally, 19 patients (50%) reported a pathological St. George’s Respiratory Questionnaire, and respectively 12 (31.6%) and 11 (28.9%) patients a pathological Short Form Survey-12 in physical and mental components. At 1-year follow-up SARS-CoV-2 pneumonia survivors still present a substantial impairment in radiological and functional findings and in health-related quality of life, despite showing a progressive recovery. Dewey 616 56 Département de médecine 221 false 436 Médecine palliative 709 Npj primary care respiratory medicine 32 1 19b5ae56-f2d4-41d1-a8f6-df9ec19a4274 Article (Published version) Public Article-scientifique-from-unpaywall.pdf 814868 application/pdf CC BY-4.0 openAccess Faculté de médecine / Section de médecine clinique / Département de médecine

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1-year radiological, functional and quality-of-life outcomes in patients with SARS-CoV-2 pneumonia - A prospective observational study	Npj primary care respiratory medicine			2022	204	162

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