Response to treatment and disease progression linked to CD4+ T cell surface CC chemokine receptor 5 density in human immunodeficiency virus type 1 vertical infection

Article Article scientifique Article Response to treatment and disease progression linked to CD4+ T cell surface CC chemokine receptor 5 density in human immunodeficiency virus type 1 vertical infection eng 2002 author Gervaix Alain 31715 author Nicolas Joëlle 723267 author Portales Pierre author Posfay Barbe Klara 39230 author Wyler Claire-Anne 527301 author Segondy Michel author Avinens Odile author Siegrist Claire-Anne 26816 author Clot Jacques author Eliaou Jean-François author Astruc Jacques author Corbeau Pierre 1055-1061 10.1086/339802 11930315 0022-1899 The factors governing interindividual variability in disease progression among children vertically infected with human immunodeficiency virus type 1 (HIV-1) remain unclear. Because it has recently been shown in infected adults that the density of CC chemokine receptor 5 (CCR5) molecules at the surface of nonactivated (human leukocyte antigen [HLA]-DR(-)) CD4+ T cells correlates with disease progression, the same correlation was sought in children. HLA-DR(-)CD4+ T cell surface CCR5 density was constant over time and correlated with the bioclinical stage and with the CD4 cell slope observed before antiretroviral treatment. In addition, CCR5 density was negatively correlated with the intensity of the decrease in viremia during antiretroviral therapy and was positively correlated with CD4 cell slope since birth. These results are compatible with the hypothesis that CCR5 density is a key factor governing disease progression in pediatric HIV-1 infection and, thereby, an indicator of prognosis. Moreover, they suggest that therapies aimed at reducing CCR5 accessibility should slow down HIV disease evolution in children. Acquired Immunodeficiency Syndrome/drug therapy/immunology/transmission Adolescent CD4-Positive T-Lymphocytes/chemistry Child Child, Preschool Female HIV-1 Humans Infant Infectious Disease Transmission, Vertical Male Receptors, CCR5/analysis Dewey 616.07 Dewey 618 137 Département de pathologie et immunologie 21F 58 Département de pédiatrie, gynécologie et obstétrique 223 false 143 Centre de Vaccinologie et d'Immunologie néonatale 177 149 Etiologie des pneumonies et marqueurs inflammatoires chez l'enfant fébrile 183 515 Recherche en infectiologie pédiatrique et en pédiatrie générale 853 The Journal of infectious diseases 185 8 1db0ac4d-8242-49b0-a8d3-4f88f2c5a725 Article (Published version) Restricted 1055-1061.pdf 130697 application/pdf restrictedAccess Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique

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Response to treatment and disease progression linked to CD4+ T cell surface CC chemokine receptor 5 density in human immunodeficiency virus type 1 vertical infection	The Journal of infectious diseases			2002	586	0

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Nicolas, Joëlle