Simulated patterns of mitochondrial diversity are consistent with partial population turnover in Bronze Age Central Europe

Article Article scientifique Article Simulated patterns of mitochondrial diversity are consistent with partial population turnover in Bronze Age Central Europe eng 2021-11-02 2022 author Broccard Nicolas 720516 author Monteiro Da Silva Nuno Miguel 778280 author Currat Mathias 0000-0001-5211-8922 89701 134-146 10.1002/ajpa.24431 2692-7691 https://onlinelibrary.wiley.com/doi/10.1002/ajpa.24431 Objectives: The analysis of ancient mitochondrial DNA from osteological remains has challenged previous conclusions drawn from the analysis of mitochondrial DNA from present populations, notably by revealing an absence of genetic continuity between the Neolithic and modern populations in Central Europe. Our study investigates how to reconcile these contradictions at themitochondrial level using amodeling approach. Materials and Methods: We used a spatially explicit computational framework to simulate ancient and modern DNA sequences under various evolutionary scenarios of post Neolithic demographic events and compared the genetic diversity of the simulated and observed mitochondrial sequences. We investigated which—if any—scenarios were able to reproduce statistics of genetic diversity similar to those observed, with a focus on the haplogroupN1a, associatedwith the spread of earlyNeolithic farmers. Results: Demographic fluctuations during the Neolithic transition or subsequent demographic collapses after this period, that is, due to epidemics such as plague, are not sufficient to explain the signal of population discontinuity detected on the mitochondrial DNA in Central Europe. Only a scenario involving a substantial genetic input due to the arrival of migrants after the Neolithic transition, possibly during the Bronze Age, is compatible with observed patterns of genetic diversity. Discussion: Our results corroborate paleogenomic studies, since out of the alternative hypotheses tested, the best one that was able to recover observed patterns of mitochondrial diversity in modern and ancient Central European populations was one were immigration of populations from the Pontic steppes during the Bronze Age was explicitly simulated. Ancient DNA Demographic fluctuation N1a mitochondrial haplogroup Plague Yamnaya Dewey 590 Swiss National Science Foundation Reconstructing Europeans' genetic evolution through computer simulations and heterochronous molecular data 31003A_156853 CH Project funding Swiss National Science Foundation Paleogenomic investigation of the Evolution of European populations using computational simulations 31003A_182577 CH Project funding 44 Département de génétique et évolution 162 false 828 Groupe Currat 682 Laboratory of Anthropology, Genetics and Peopling history (AGP) 1056 Unité d'anthropologie American journal of biological anthropology 177 1 d34fe921-b104-4d8d-926d-68ce647f4ac1 Article (Published version) Public Broccard_et_al_AJBA_21.pdf 2160834 application/pdf openAccess Faculté des sciences / Section de biologie / Département de génétique et évolution

Title	Published in	Year	Views	Downloads

Simulated patterns of mitochondrial diversity are consistent with partial population turnover in Bronze Age Central Europe	American journal of biological anthropology	2022	479	292
Inférence de l'histoire démographique post-néolithique européenne par simulation informatique		2016	150	4

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Broccard, Nicolas