Long term anti-SARS-CoV-2 antibody kinetics and correlate of protection against Omicron BA.1/BA.2 infection

Article Article scientifique Article Long term anti-SARS-CoV-2 antibody kinetics and correlate of protection against Omicron BA.1/BA.2 infection eng 2023-05-26 2023-05-26 author Perez-Saez Javier Unit of Population Epidemiology, Division of Primary Care Medicine, Geneva University Hospitals, Geneva, Switzerland. javier.perez@hcuge.ch.,Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. javier.perez@hcuge.ch. author Zaballa Maria-Eugenia 0000-0002-0613-9519 Unit of Population Epidemiology, Division of Primary Care Medicine, Geneva University Hospitals, Geneva, Switzerland. author Lamour Julien 0000-0003-3129-1974 Unit of Population Epidemiology, Division of Primary Care Medicine, Geneva University Hospitals, Geneva, Switzerland. author Yerly Ferrillo Sabine 0000-0003-1668-696X Division of Laboratory Medicine, Department of Diagnostics, Geneva University Hospitals, Geneva, Switzerland. 23752 author Dubos Richard Unit of Population Epidemiology, Division of Primary Care Medicine, Geneva University Hospitals, Geneva, Switzerland. author Courvoisier Delphine 0000-0002-1956-2607 General Directorate of Health, Geneva, Switzerland.,Division of Quality of Care, Geneva University Hospitals, Geneva, Switzerland. 94475 Département de médecine (DEMED) author Villers Jennifer Annick M. 0000-0003-3832-3481 Unit of Population Epidemiology, Division of Primary Care Medicine, Geneva University Hospitals, Geneva, Switzerland. 941947 author Balavoine Jean-François Department of Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland. 23999 author Pittet Didier Department of Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland.,Infection Control Program and World Health Organization Collaborating Centre on Patient Safety, Geneva University Hospitals, Geneva, Switzerland. 117792 Décanat et administration de la faculté de médecine (ADMED) author Kherad Omar Department of Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland.,Division of Internal Medicine, Hôpital de la Tour, Geneva, Switzerland. 509928 Département de médecine (DEMED) author Vuilleumier Nicolas Division of Laboratory Medicine, Department of Diagnostics, Geneva University Hospitals, Geneva, Switzerland.,Department of Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland. 61406 Département de médecine (DEMED) author Kaiser Laurent Division of Laboratory Medicine, Department of Diagnostics, Geneva University Hospitals, Geneva, Switzerland.,Department of Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland.,Division of Infectious Diseases, Department of Medicine, Geneva University Hospitals, Geneva, Switzerland.,Geneva Centre for Emerging Viral Diseases, Geneva University Hospitals, Geneva, Switzerland. 28229 Département de médecine (DEMED) author Guessous Idris 0000-0002-0491-6089 Department of Health and Community Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland.,Division and Department of Primary Care Medicine, Geneva University Hospitals, Geneva, Switzerland. 760565 Médecine de premier recours hospitalo-universitaire (MPRHU) author Stringhini Silvia 0000-0002-4387-8943 Unit of Population Epidemiology, Division of Primary Care Medicine, Geneva University Hospitals, Geneva, Switzerland.,University Centre for General Medicine and Public Health, University of Lausanne, Lausanne, Switzerland. 830749 Médecine de premier recours hospitalo-universitaire (MPRHU) author Azman Andrew 0000-0001-8662-9077 Unit of Population Epidemiology, Division of Primary Care Medicine, Geneva University Hospitals, Geneva, Switzerland.,Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. 954616 Specchio-COVID19 study group collaborator Arm-Vernez Isabelle 690605 collaborator Bal Antoine collaborator Barbe Remy 527289 collaborator Baysson Hélène 0000-0003-4676-4500 927962 Hélène BAYSSON collaborator Berthelot Julie collaborator Bryand Gaelle 133381 collaborator Chappuis François 34709 Département de santé et médecine communautaire (MECOM) collaborator Collombet Prune 930845 collaborator Coudurier-Boeuf Sophie 713250 collaborator De Mestral Carlos collaborator D'ippolito Paola collaborator Dumont Roxane 822214 collaborator El Merjani Nacira collaborator Flahault Antoine 815316 Institut de santé globale (COSPR) collaborator Francioli Natalie collaborator Graindorge Clément 715410 collaborator Harnal Severine 417938 collaborator Hurst Samia 0000-0002-1980-5226 84281 iEH2 (COETH) collaborator Lescuyer Pierre 0000-0001-6986-8738 562350 collaborator L'Huillier Arnaud 0000-0001-9230-7285 543058 Département de Pédiatrie, Gynécologie et Obstétrique (PETRI) collaborator Loizeau Andréa 677311 collaborator Lorthe Elsa Louise Adèle 416911 collaborator Martinez Chantal 591418 collaborator Metral-Boffod Ludovic 647651 collaborator Nehme Mayssam 840942 collaborator Noël Natacha collaborator Pennacchio Francesco collaborator Posfay Barbe Klara 39230 Département de Pédiatrie, Gynécologie et Obstétrique (PETRI) collaborator Poulain Géraldine 868190 collaborator Pugin Caroline 926418 collaborator Pullen Nick collaborator Richard Viviane Adissa 899625 collaborator Rochat Michèle Deborah 83757 collaborator Samir Khadija 417937 collaborator Santa-Ramirez Hugo 943645 Département de médecine génétique et développement (GEDEV) collaborator Satin Etienne collaborator Schaller Philippe 42706 collaborator Schrempft Stéphanie 931965 collaborator Semaani Claire collaborator Testini Stéphanie 808001 collaborator Urrutia Rivas Deborah 840320 collaborator Verolet Charlotte 646895 collaborator Violot Guillemette collaborator Wisniak Ania 717179 ania Wisniak 3032 10.1038/s41467-023-38744-7 37230973 2041-1723 PMC10212737 Binding antibody levels against SARS-CoV-2 have shown to be correlates of protection against infection with pre-Omicron lineages. This has been challenged by the emergence of immune-evasive variants, notably the Omicron sublineages, in an evolving immune landscape with high levels of cumulative incidence and vaccination coverage. This in turn limits the use of widely available commercial high-throughput methods to quantify binding antibodies as a tool to monitor protection at the population-level. Here we show that anti-Spike RBD antibody levels, as quantified by the immunoassay used in this study, are an indirect correlate of protection against Omicron BA.1/BA.2 for individuals previously infected by SARS-CoV-2. Leveraging repeated serological measurements between April 2020 and December 2021 on 1083 participants of a population-based cohort in Geneva, Switzerland, and using antibody kinetic modeling, we found up to a three-fold reduction in the hazard of having a documented positive SARS-CoV-2 infection during the Omicron BA.1/BA.2 wave for anti-S antibody levels above 800 IU/mL (HR 0.30, 95% CI 0.22-0.41). However, we did not detect a reduction in hazard among uninfected participants. These results provide reassuring insights into the continued interpretation of SARS-CoV-2 binding antibody measurements as an independent marker of protection at both the individual and population levels. Humans COVID-19 SARS-CoV-2 Antibodies, Viral Immune Evasion Kinetics Antibodies, Neutralizing Dewey 613 Dewey 616 Dewey 618 56 Département de médecine 221 64 Département de santé et médecine communautaires 22A 58 Département de pédiatrie, gynécologie et obstétrique 223 false 526 Résistance aux antibiotiques 866 400 Groupe Laurent Kaiser (virologie clinique) 668 875 Groupe Courvoisier 1313 Médecine de 1er recours 1020 907 Groupe Flahault Antoine 945 453 Ethique biomédicale 783 515 Recherche en infectiologie pédiatrique et en pédiatrie générale 853 https://github.com/UEP-HUG/serosuivi_2021_public Nature communications 14 1 9e38dc4d-30f0-4a7e-85b9-aaf4e9330159 Article (Published version) Public Article-scientifique-from-unpaywall.pdf 2648430 application/pdf CC BY-4.0 c61e2af0504c45100a79335d06d20b22dfd0e2a50df32d059fd029c216ed10b0 2cc265ba-0cb9-49e8-ab39-b58a2e32116c Appendix Public 41467_2023_38744_MOESM1_ESM.pdf 11968460 application/pdf bece63e3f718b058f4e6868536308e8cffe80c83a0200a267ce5a0c80e1bea61 e447194f-e99e-48e5-acd2-8b0f19349f15 Appendix Public 41467_2023_38744_MOESM2_ESM.pdf 402902 application/pdf fd2bbe650ec1acb3feb1f12a3a6c1e28989716b6cfb748ed742c52abfdd05f55 openAccess Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine clinique / Département de santé et médecine communautaires Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique

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Long term anti-SARS-CoV-2 antibody kinetics and correlate of protection against Omicron BA.1/BA.2 infection	Nature communications			2023	95	24

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Coudurier-Boeuf, Sophie