Depression and anxiety disorders in children and adolescents with velo-cardio-facial syndrome (VCFS)

Article Article scientifique Article Depression and anxiety disorders in children and adolescents with velo-cardio-facial syndrome (VCFS) eng 2012 author Fabbro Alice 709225 author Rizzi Eleonora 594679 author Schneider Maude 594384 author Debbané Martin 543333 author Eliez Stéphan 39336 379-385 10.1007/s00787-012-0273-x 22526976 1018-8827 Velo-cardio-facial syndrome (VCFS) is characterized by a high prevalence of depression and anxiety disorders in childhood and adolescence. These disorders are a source of great impairment in everyday functioning, as well as important risk factors for the emergence of later psychotic disorders. Impairment in daily and social functioning as well as loss of IQ throughout growth are also are well-established correlates of the VCFS. This study aimed to confirm the high prevalence of depression and anxiety disorders. The second objective was to ascertain the correlation between anxious and depressive symptoms and the decline in adaptive and cognitive functioning. A total of 73 children and adolescents with VCFS (mean age 11.9 years) underwent psychiatric evaluation. Subjects were further divided into four age groups: ages 6-9, 9-12, 12-15 and 15-18 years. Assessments measuring intelligence, anxious and depressive symptoms, and adaptation skills reported by parents were submitted to a subsample of 62 children (mean age 12.2 years); 62.2 % of the sample showed an anxiety disorder, specific phobia being the most represented at all ages. Lifetime depression concerned 27 % of the sample, peaking at age 12-15 years. Anxious and depressive symptoms and low IQ were significantly associated with low adaptive functioning. Anxiety and depression are common disorders in children and adolescents with VCFS and have a great impact on adaptive functioning. Clinicians should pay great attention to diagnosis and treatment. Adaptation, Psychological Adolescent Anxiety/complications/diagnosis Anxiety Disorders/complications/diagnosis Child Depression/complications/diagnosis Depressive Disorder/complications/diagnosis DiGeorge Syndrome/complications/psychology Female Humans Intelligence Tests Male Psychiatric Status Rating Scales Dewey 150 Dewey 616.89 Open Access - Licence nationale Springer 60 Département de psychiatrie 225 108 Section de psychologie 71 false 421 Laboratoire d'imagerie et de psychopathologie développementale 693 603 Unité de psychologie clinique de l'adolescence (UPCA) European child & adolescent psychiatry 21 7 3178fff7-4976-42d7-8ce4-512168c33926 Article (Published version) Public Fabbro2012_ECAP.pdf 200575 application/pdf openAccess Faculté de médecine / Section de médecine clinique / Département de psychiatrie Faculté de psychologie et des sciences de l'éducation / Section de psychologie

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Depression and anxiety disorders in children and adolescents with velo-cardio-facial syndrome (VCFS)	European child & adolescent psychiatry			2012	898	504

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Fabbro, Alice