Heat shock proteins in ovarian cancer: a potential target for therapy

Article Article scientifique Revue de la littérature Heat shock proteins in ovarian cancer: a potential target for therapy eng 2010 author Cohen Marie-Benoîte 0000-0003-4621-5464 135615 author Dromard Mathilde 705481 author Petignat Patrick 586685 164-166 10.1016/j.ygyno.2010.05.027 20580418 0090-8258 Ovarian cancer is the leading cause of death from gynecologic cancer in Western countries. Most of the patients are chemosensitive, and they will present a complete response after initial treatment, but most of them will relapse within 2 years. The resistance to standard chemotherapy represents a significant clinical challenge. Therefore, a better understanding of the molecular mechanisms involved in the drug resistance should allow to improve the treatment in this disease. Interestingly, recent data showed essential roles of heat shock proteins (HSPs) in various processes of carcinogenesis and their association with resistance to anticancer drugs. Here, we report the main investigations on HSPs in ovarian cancer with specific emphasis on clinical application. Drug Delivery Systems/methods Drug Resistance, Neoplasm Female Heat-Shock Proteins/metabolism Humans Ovarian Neoplasms/drug therapy/metabolism Dewey 618 58 Département de pédiatrie, gynécologie et obstétrique 223 false 584 Laboratoire de biologie des tumeurs gynécologiques et du développement 927 590 Prévention du cancer du col utérin 933 Gynecologic oncology 119 1 eb1ad86c-42ec-4f41-a6d9-6137441ec74a Article (Published version) Restricted 20580418.pdf 149974 application/pdf restrictedAccess Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique

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Heat shock proteins in ovarian cancer: a potential target for therapy	Gynecologic oncology			2010	656	2

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Dromard, Mathilde