The perioperative use of synthetic and biological disease-modifying antirheumatic drugs in patients with rheumatoid arthritis

Article Article scientifique Article The perioperative use of synthetic and biological disease-modifying antirheumatic drugs in patients with rheumatoid arthritis eng 2017 author Fleury Gregory Stéphane 510966 author Mania Sylvano Anis 0000-0003-4844-5351 701820 author Hannouche Didier 0000-0003-2060-2394 842478 author Gabay Cem 70978 w14563 10.4414/smw.2017.14563 29231235 1424-7860 Disease-modifying antirheumatic drugs (DMARDs) have become essential treatments in the management of patients with inflammatory rheumatic diseases. Their use has resulted in a marked improvement of disease control and a limitation of joint damage, although some patients still require subsequent corrective or joint replacement surgery. Due to their immunosuppressive effects, some DMARDs are associated with an increased risk of infection. The aim of this review is to discuss the available literature on the management of DMARDs during the perioperative period, particularly in the case of orthopaedic surgery. Conventional synthetic DMARDs such as methotrexate, sulfasalazine, leflunomide, hydroxychloroquine appear to be safe during the perioperative period. Conflicting results on biological DMARDs, mainly tumour necrosis factor antagonists, are reported in the literature, including both increased and unchanged risk of superimposed infections after surgery. Taking into account the available literature, we included some propositions for the management of patients who will undergo surgical interventions. Dewey 616 Dewey 617 56 Département de médecine 221 57 Département de chirurgie 222 false 28 Mécanisme de l'inflammation articulaire 44 955 Thérapie cellulaire et troubles musculo-squelettiques 960 Swiss Medical Weekly 147 dc9ebc45-002b-4207-8684-48ce0902d0c5 Article (Published version) Public 29231235.pdf 852244 application/pdf CC BY-NC-ND openAccess Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine clinique / Département de chirurgie

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The perioperative use of synthetic and biological disease-modifying antirheumatic drugs in patients with rheumatoid arthritis	Swiss Medical Weekly			2017	526	255

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Mania, Sylvano Anis

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